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Showing 1 to 2 of 2 for “"Epithelial PR"”.

  1. Suppression of Cervical Cancer by the Progesterone Receptor Signaling

    … potential stems mainly from viral oncoproteins E6 and E7, which are best known to inactivate p53 and pRb tumor suppressor, respectively. Epidemiological evidence suggests that, in addition to persistent HPV infections, other cofactors are required for cervical cancer. Multiple …

    houston Repository record for Suppression of Cervical Cancer by the Progesterone Receptor Signaling (opens in a new tab)

  2. Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix

    … cervical cancer. High–risk HPV E6 and E7 oncoproteins promote cell proliferation by inactivating p53 and pRb cellular tumor suppressors, respectively, which accelerates cervical carcinogenesis. However, HPV is not sufficient for cervical cancer. Epidemiologic evidence suggests that females sex …

    houston Repository record for Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix (opens in a new tab)