Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Epithelial Ovarian Cancer"”.
-
Modeling Epithelial Ovarian Cancer In The Mouse
For over five decades epithelial ovarian cancer (EOC) is identified as the leading cause of death from gynecological malignancies in the USA. Unfortunately, due to latent progression of EOC and lack of accurate animal models studies of this disease's pathogenesis have been challenging. Not …
-
Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a …
-
Lifetime Caffeine Intake and the Risk of Epithelial Ovarian Cancer
… between lifetime caffeine intake and the risk of epithelial ovarian cancer (EOC) overall, according to tumour behaviour (invasive vs. borderline), and by invasive tumour type (Type I vs. Type II) and to assess menopausal status as an effect modifier. Methods: The PRevention of OVArian Cancer in …
-
Improving quality of clinical care in epithelial ovarian cancer patients
Contains fulltext : 108279.pdf (Publisher’s version ) (Open Access)
-
Influencing Pathways that Cause Metastasis and Stemness in Epithelial Ovarian Cancer
<p>Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian …
-
The Role Of Oxidative Stress In The Pathogenesis Of Epithelial Ovarian Cancer
<p>Ovarian cancer is the leading cause of death from gynecologic malignancies yet the underlying pathophysiology is not clearly established. The disease is usually diagnosed in the advanced stage and carries a poor prognosis. The 5-year survival rate is greater than 75% if diagnosis of the cancer …
-
The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
<p>Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer death among women in the United States. The high lethality of EOCs stems from rapid peritoneal involvement. EOCs frequently colonize peritoneal surfaces that overlie connective and adipose tissues. However, the mechanisms that …
-
Functions of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling and Metastasis of Epithelial Ovarian Cancer
<p>Epithelial ovarian cancer (EOC) accounts for the most number of deaths among women with gynecological malignancies in the United States. Approximately 80% of EOC patients are diagnosed with disease that has disseminated beyond the confines of the ovaries. The five year survival rate for patients …
-
Epitelinio kiaušidžių vėžio predikcinių imuninių žymenų paieška /
… The Search for Predictive Immune Biomarkers of Epithelial Ovarian Cancer The aim of the study: To identify predictive immune biomarkers of chemotherapy resistance in the epithelial ovarian tumor microenvironment and peripheral blood, and to investigate the relationships among them. Objectives: …
-
ING1 Impacts Ovarian Cancer by Altering EMT
… the potential role of ING1 in inhibiting the epithelial-mesenchymal transition (EMT) program that suppresses cancer metastasis and identifies the mechanism of how ING1 regulates gene transcription, as well as its clinical implication in epithelial ovarian cancer. Our analyses revealed that …
-
Regulation of Cyclin G2 Degradation in Human Ovarian Cancer Cells
Epithelial ovarian cancer has the highest mortality rate among gynecological malignancies. Uncontrolled cell growth lies at the core of EOC. Normal cell cycle progression is governed by temporal expression of canonical cyclin molecules, which then bind to and activate CDKs. Cyclin G2, an …
-
Exploring The Relationship Between Mitochondrial-linked Cell Death And Muscle Atrophy During Ovarian Cancer Progression
The mechanisms underlying muscle atrophy during ovarian cancer are not fully understood. This study investigated the role of mitochondrial hydrogen peroxide (mH2O2)-mediated apoptosis and necroptosis in muscle atrophy using an orthotopic epithelial ovarian cancer (EOC) model at 40 and 80 days of …
-
Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer and urgently requires new therapies. Oncolytic viruses (OV) are a strong contender. OVs interact with immune components of the TME, which can be altered due to specific genetic mutations. The present study evaluates the impact of …
-
AN INVESTIGATION OF POTENTIAL MECHANISMS UNDERLYING CHEMOSUPPRESSIVE EFFECTS OF DIETARY FLAXSEED IN THE LAYING HEN MODEL OF OVARIAN CANCER
Epithelial ovarian cancer is the most lethal gynecologic malignancy, with a 5-year survival rate of less than 40%. This is due in part to a lack of early detection markers and lack of specific symptoms during early disease. The laying hen is the only accessible animal model which develops …
-
Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
<p>Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. In epithelial ovarian cancer, the mechanisms driving lymph node (LN) metastasis are poorly understood, and it …
-
Investigating the Anti-Tumor Effects of Two Novel B-Catenin Inhibitors in Ovarian Cancer Cells
Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The development of chemoresistance and relapse becomes a major challenge in treating ovarian cancer. The Wnt/-catenin pathway, which plays a critical role in developmental and physiological processes, have been indicated to …
Page 1 of 3