Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Epithelial Differentiation"”.
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THE NRF-1/GABP/BRCA1 Transcriptional Network in Mammary Epithelial Differentiation
… in a hierarchy in which mature luminal and myoepithelial cells are derived from stem cells through a series of lineage-restricted intermediates. One of the more compelling hypotheses in breast cancer research is that transformation of a particular cell within the hierarchy will initiate a …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… plays a vital role in the regulation of lineage differentiation during development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal cancer, KLF4 was …
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New technologies and methodologies for the study of human mammary epithelial differentiation and development
… cell types. Thus, understanding how mammary differentiation is regulated has long been a goal in oncology and developmental biology. Researchers have relied on animal models and in vitro assays to study mammary development for decades. However, differences between the human and murine gland, …
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Small Proline Rich Protein-2 Expression and Regulation in the Caco-2 model of Intestinal Epithelial Differentiation along the Crypt-Villus Axis
… unexplored. Using the Caco-2 model of intestinal epithelial differentiation along the crypt-villus axis, we hypothesized that SPRR2 would be preferentially expressed in post-confluent differentiated Caco-2 cells and examined SPRR2 regulation by the protein kinase A pathway (PKA) and short chain …
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HUMAN CLCA2 IS A P53-DEPENDENT ZINC METALLOPROTEASE AND ITS INTERACTION WITH EVA1 MAINTAINS DIFFERENTIATION OF HUMAN MAMMARY EPITHELIAL CELLS
… CLCA2 plays an essential role in epithelial differentiation. It is induced during epithelial differentiation in immortalized human mammary epithelial cells (HMEC), and its knockdown causes epithelial to mesenchymal transition (EMT). To determine how CLCA2 promotes epithelial …
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Roles in Retinoid Signaling in the Lower Urinary Tract
… including formation of most embryonic tissues, epithelial differentiation, and is a critical regulator of stem cell differentiation in vitro. Studies from our lab have focused on the role of RA-signaling in the urinary tract, where we find that it plays multiple roles. By inducing expression of …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… In vitro, cyclic strain promotes intestinal epithelial proliferation and induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase (DPPIV) expression. Schlafen 3 is a novel gene recently associated with cellular differentiation. We sought to evaluate whether Schlafen 3 …
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The role of hCLCA2 and hCLCA4 in suppression of breast cancer progression
… regulators that are expressed in normal breast epithelial cells and frequently downregulated in breast cancers. Recent investigations revealed that these two proteins may have a role in suppressing breast cancer progression. In this thesis, I will address their role in maintaining epithelial …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… out to explore the impact of hypoxia on mammary epithelial differentiation and what consequences the hypoxic response might have on breast cancer development and behavior. We found that hypoxia induces a less differentiated, estrogen receptor (ER)-negative/cytokeratin (CK) 19-positive phenotype …
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hCLCA2 IS A p53-REGULATED GENE REQUIRED FOR MESENCHYMAL TO EPITHELIAL TRANSITION IN BREAST
… regulator that is expressed in normal breast epithelial cells and frequently down-regulated in breast cancers. The first CLCA protein was described as a calcium-activated, plasma-membrane chloride channel having four or five transmembrane pass structure that could form a channel pore. However, …
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The diversity of malignant rhabdoid tumours : a morphological, immunohistochemical and ultrastructural review of cases from the Red Cross Children's Hospital and Groote Schuur Hospitals
… Groote Schuur Hospital. In this series primitive epithelial elements are a dominant feature, but ultrastructural features of one renal rumour suggest diverse differentiation. The extra-renal lesions investigated include three undifferentiated rhabdoid lesions, a primitive neuro-ectodermal tumour, …
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Mapping the Landscape of Acquired Vulnerabilities in Ovarian Cancer
… of this miRNA revealed it promoted a cell differentiation program. Analysis of predicted targets revealed that expression of miR-124a reduced expression the homeodomain transcription factor SIX4, resulting in increased signaling along the tumor suppressive AMPK pathway and epithelial …
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… in the liver, kidney, pancreas, and other epithelial organs. During kidney development, HNF-1Beta is expressed in renal collecting ducts and all segments of the nephron. Mutation of HNF-1Beta causes maturity-onset diabetes of the young type 5 (MODY5) and kidney developmental anomalies …
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AMNIOTIC MEMBRANE TRANSPLANTATION FOR OCULAR SURFACE RECONSTRUCTION IN VETERINARY MEDICINE
… healthy substrate that facilitates migration of epithelial cells, reinforces adhesion of basal epithelial cells, promotes epithelial differentiation, and prevents epithelial apoptosis. Additionally AM produces various growth factors, inhibits protease activity, has anti-inflammatory, …
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The role of probiotics, prebiotics, and human milk oligosaccharides in infant formulae
… of a model HMO, and; 2) assess the induction of ‘epithelial differentiation’ by three individual HMOs using an in vitro epithelial model of the crypt-villus axis. In study 1, pre-confluent HT-29, pre-confluent Caco-2Bbe, confluent Caco-2Bbe, and post-confluent Caco-2Bbe cells were cultured …
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Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… the development and maintenance of stratified epithelial tissues, unlike p53. p63 is highly expressed in the epidermis and previously has been shown to play a critical role in the development and maintenance of the epidermis. The study of p63 has been complicated due to the existence of …
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A Proteomic Analysis of Differentiation in the Mammary Epithelium
… known about the molecular mechanisms governing differentiation of the mammary epithelium into a milk-secreting phenotype. It is important to acknowledge the diversity among the mammary glands of different species in order to better understand applications in human health and the dairy industry. …