Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1043 for “"Epithelial Cells"”.
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Dissection of CD2AP functions in epithelial cells
… molecular mechanism that determines the shape of epithelial cells. Epithelial cells are characterized by extensive cell-cell contacts along lateral membranes that hold the cells together in cohesive sheets and by a pronounced apical-basal polarity in which the apical domain faces a lumen and the …
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Xenogeneic transplantation of immortalized bovine mammary epithelial cells
… the use of an immortalized bovine mammary epithelial cell line as a starting material for xenogeneic transplantation into the mammary glands of immunocompetent recipients. PSG-5 cells (a clonal derivative of the MAC-T cell line engineered to express ovine IGF-I ) were transplanted into the …
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The Transformation of Human Retinal Pigment Epithelial Cells
… barrier, and inflammation. Retinal pigment epithelial (RPE) cells, a single layer of cuboidal epithelium located at the back of eye behind neural retina, gain access and proliferate in the vitreous during PVR. RPE cells in the vitreous undergo epithelial-mesenchymal transformation (EMT) and …
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Molecular mechanism of magnesium transport in epithelial cells
… and Ca 2 homeostasis in the pancreatic acinar cells and parietal cells and (b) to characterise the molecular mechanism of Mg 2 transport using fluorimetric and spectroscopic studies. The results have shown that application of either cholecystokinin-octapeptide (CCK-8) or acetylcholine (ACh) to …
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Pathways for mechanotransduction in pressurized airway epithelial cells
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2001.
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The intrinsic role of SOCS1 in intestinal epithelial cells
… signaling. To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative colitis might be driven by Paneth and …
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Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
… and epoxy resins, rapidly injures biliary epithelial cells (BEC) of rats in vivo. DAPM also increases biliary inorganic phosphate and glucose, suggesting that DAPM loosens hepatic tight junctions. Early ultrastructural alterations in BEC mitochondria, however, suggested a possible role of …
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Protein sorting to the apical membrane of epithelial cells
… proteins to the apical membrane of polarised cells. Based on this, the aim of this work was to contribute to the understanding of apical sorting in epithelial cells. The study of how lipid rafts are structured has been hampered by the scarcity of techniques for their purification. Rafts are …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… a role for BMP signalling in adult airway epithelial cells (AECs) and to further investigate BMP signalling during airway inflammation. AECs used included the transformed bronchial cell line, BEAS-2B, the adenocarcinoma-derived cell line, A549, and normal primary murine airway epithelial …
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THE ROLE OF ROMA IN MOUSE MAMMARY EPITHELIAL CELLS
Epithelial to Mesenchymal Transition (EMT) and its reversal, via Mesenchymal to Epithelial Transition (MET), describes the highly coordinated cycle of epithelial plasticity by which normal tissues are remodelled and repositioned during development. Previous studies have characterised the role of …
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… mechanisms of protein sorting in polarized epithelial cells are poorly understood. Several studies have determined membrane targeting of G protein-coupled receptors (GPCRs) using epithelial cells such as Madin-Darby canine kidney (MDCK) cells. Polarized epithelial cells are composed of …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… is infection across the vaginal mucosa. Epithelial cells, which form the primary barrier of protection against pathogens, are the first cell type at these mucosal tissues to encounter the virus but their role in HIV infection has not been clearly elucidated. Although mucosal epithelial …
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Organization and formation of the apical membrane of epithelial cells
… of this unique plasma membrane domain during epithelial polarization. The apical membrane of columnar epithelia is enriched in glycosphingolipids, a class of lipids that are known to interact with cholesterol to form liquid ordered domains, also termed "rafts", in cell membranes. …
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Expression of Peroxiredoxin Induced by Silica in Alveola Epithelial Cells
" 폐암을 비롯한 여러 종류의 고형암 및 임상에서 자주 접하는 여러 종류의 각종 만성 염증질환에서는 발암물질과 여러 종류의 성장인자에 의한 만성적이며, 지속적인 자극과 함께, 계속적인 산화 스트레스를 통해 세포의 성장과 증식 및 주변 조직으로의 침습에 대한 자극이 동시에 공존한다고 할 수 있다. 비교적 최근에 알려진, 새로운 계통의 항산화 효소인 peroxiredoxin (Prx)은 세포의 증식과 분화, 세포사멸이나 발암과정에 관여하는 것으로 알려져 있다. 더구나, 이들 Prx 는 thioredoxin (Trx)과 더불어 …
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Mechanotransduction via airway epithelial cells : the effect of compressive stress
… vitro system of cultured normal human bronchial epithelial cells that could simulate compressive stresses experienced by the epithelium during bronchoconstriction. The application of a transcellular pressure gradient (10-50cmH20) for 10 minutes resulted in transient activation of the epidermal …
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