Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Epirubicin"”.
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Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity
… the clinical application of these drugs.</p> <p>Epirubicin (EPI) is a topoisomerase II Inhibitor and an antineoplastic agent used to treat acute myeloid leukemias, multiple sclerosis (relapsing or secondary progressive), and prostate cancer. However, this agent causes myocardial toxicity and …
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Effetti cardiotossivi precoci e tardivi del trattamento con Epirubicina. Valutazione con marker biochimici ed ecocardiografia Tissue Doppler.
Our study was carried out in a group of epirubicin(Epi)-treated patients with cancer at different sites with the aim of detecting early preclinical changes, that are predictive of the risk of heart failure. All subjects underwent conventional echocardiography, as well as tissue Doppler imaging …
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Effectiveness of a closed system device in reducing occupational exposure and environmental concentrations of anticancer drugs
… preparation of five anticancer drug infusions (epirubicin, fluorouracil, cisplatin, oxaliplatin and carboplatin) in a pharmaceutical isolator and external surfaces of infusion bags and syringes using a conventional syringe and needle technique was investigated and compared with that obtained …
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Does hair curl variation influence the efficacy of scalp cooling in the prevention of chemotherapy-induced alopecia in breast cancer patients? A randomized controlled pilot study
… cancer to receive chemotherapy (Adriamycin or Epirubicin and Cyclophosphamide followed by Paclitaxel) with or without scalp cooling. The main outcomes were percentage alopecia (Severity ALopecia Tool scored by 3 dermatologists) in straight versus curly hair and treatment retention rates. …
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Mechanisms of multidrug resistance in bladder cancer: the role of the nuclear membrane
… using mitomycin C or epirubicin (an anthracycline), following<br/>surgical resection. However, despite this treatment, the recurrence rates of<br/>these tumours can approach 60%. This high recurrence rate represents the<br/>development of MDR in many …
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Optimization of Optical Nanosensor Response for the Detection of Anthracyclines Using a Binary Machine Learning Classifier
… study, anthracyclines Daunorubicin, Doxorubicin, Epirubicin, Mitoxantrone and Idarubicin, were used to interrogate 12 SWCNT preparations wrapped with separate oligonucleotide sequences. In triplicate, the near-infrared fluorescence responses of each combination of oligonucleotide and anthracycline …
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Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
… pulse-selection of three cell lines with epirubicin, taxotere and gemcitabine. The drug-selected cell lines, in general, displayed low changes in sensitivity to their respective selecting drugs and no obvious cross-resistance profile. However, drug treatment modulated the invasive …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… who received neoadjuvant therapy consisting of epirubicin with cyclophosphamide followed by docetaxel. Comparative proteomic analysis was performed, to identify differentially expressed proteins (DEPs) between CS and CR invasive ductal carcinoma samples, using 2-dimensional polyacrylamide gel …
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An investigation of some chromatographic and electrophoretic seperations for industrial and clinical applications
… the anthracyclines, daunombicin, doxorubicin and epirubicin. Ultra-violet (UV), electrochemical (EC) and laser-induced fluorescence (LIF) detection coupled to CE were investigated. Improved detection limits (150-1400 ng ml-') were obtained with LIF detection, which were capable of monitoring the …
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Υπολογιστικές προσομοιώσεις διαγνωστικών και θεραπευτικών τεχνικών που αφορούν σε φυσιολογικά και παθολογικά κυτταρικά συστήματα
… σχήματα χορήγησης των σκευασμάτων: επιρουβικίνη (epirubicin), τεμοζολομίδη (temozolomide), σισπλατίνη (cisplatin), γεμσιταμπίνη (gemcitabine), βινορελμπίνη (vinorelbine) και δοσεταξέλη (docetaxel). Σκοπός της εργασίας είναι η ανάπτυξη ενός εργαλείου για την αξιόπιστη υποστήριξη ιατρών στη λήψη …
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Identification of novel biomarkers and therapeutic strategies in triple negative breast cancer
… to increased resistance to FEM (5- fluorouracil, epirubicin, mitomycin C) and docetaxel treatment in the LAR TNBC cell line, MDA-MB-453. Moreover, stimulation of GR using a synthetic agonist, dexamethasone, increased the sensitivity of this cell line to FEM chemotherapy. The GR-regulated effects …
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Prevention of cancer therapy related cardiotoxicity: A Tayside Pharmaco-Epidemiology study (PROTECT-TAYSIDE study)
Cancer is the second highest cause of death in the world after cardiovascular disease. Despite the success of chemotherapeutic agents many patients are left with the unfortunate side effects of these drugs. Cytotoxic antibiotics such as anthracyclines and the monoclonal antibody trastuzamab are …