Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Epiregulin"”.
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
… lack of novel and effective therapeutic targets. Epiregulin (EREG), is an epidermal growth factor receptor (EGFR) ligand that is highly expressed in CRCs of different subtypes and mutational statuses with low expression in normal tissues. Here, we have characterized the role of EREG in CRC …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… family growth factors, neuregulin-1, epigen and epiregulin, which act via the ERBB receptors on the mammary epithelial cells. Interestingly, exposure of these cells to the EGF-like growth factors stimulated CUZD1 expression, triggered its nuclear translocation, and promoted CUZD1-dependent …
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Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
… lactation. We also noted that the expression of epiregulin (EREG), an EGF family growth factor regulated directly by STAT5, is suppressed in Cuzd1-null mammary gland. Protein interaction studies, using flag-tagged CUZD1 expressed in HC11 mouse mammary epithelial cells, revealed that CUZD1 …