Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Epileptogenesis"”.
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Epileptogenesis Causes Long-Term Plasticity Changes in Calbindin D-28k in the Rat Pilocarpine Model of Acquired Epilepsy
… levels play a role in initiating and maintaining epileptogenesis (the development of epilepsy). Collaborations between our lab and others have produced microarray data that suggests that a major calcium-binding protein, calbindin D-28k, mRNA levels are decreased in epileptic rats even up to one …
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The Effect of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Glucose Metabolism and Epileptogenesis in the Rat
<p>Anatomic connections between the dorsal raphé and the hippocampus have been described in the literature; however, the understanding of the functional importance of these connections is not complete. In these studies the "functional" raphé-hippocampal pathway was elucidated first by the …
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
… following SE-induced brain injury can initiate epileptogenesis and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis is the process wherein healthy brain tissue is transformed into hyperexcitable neuronal …
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Identifying Key Regulators of the Immune/Inflammatory Response for Developing Anticonvulsive and Antiepileptogenic Approaches
… a pathological process occurring in experimental epileptogenesis and in human epilepsy. Interleukin-1β (IL-1β)/IL-1Receptor type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental …
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IDENTIFYING THE GENETIC MECHANISMS IN SEIZURE THRESHOLD REGULATION
… and inhibitory neurotransmission in the brain. Epileptogenesis, the transition from normal brain to epileptic brain, is accompanied by a progressive reduction of seizure threshold and has been shown to have genetic influences. Expression of neuronal cyclooxygenase-2 (COX-2) gene, PTGS2, a …
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Modulating System xc- Activity As A Treatment For Epilepsy
… underlying pathological processes involved in epileptogenesis. The overarching goal of this project is to further characterize the role astrocytes play in epileptogenesis, in hopes of revealing novel therapeutic targets to benefit patients who otherwise have no effective treatment options. …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… was initiated to evaluate the effect of epileptogenesis on the distribution and function of the endogenous CBI receptor system in the rat pilocarpine model, a well-established model of acquired temporal lobe epilepsy. Using immunohistochemistry, we demonstrated that chronically epileptic …
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Development and Characterization of Pre-Clinical Epilepsy Models to Evaluate Potential Anti-Seizure Targets.
… and is appropriate to use in research for epileptogenesis as well as screening for potential disease modifying theories. Next, we have pharmacologically characterized Kv1.1 KO mice to be potentially incorporated in the anti-epileptic drug development program as a model for drug resistant …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… seizures that correspond to both epileptogenesis (a time before the appearance of an epileptic condition) and a chronic period of spontaneous recurrent seizures (SRS). CaV3.2, along with an additional isoform CaV3.3, is also upregulated during repeated, intermittent ethanol …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… here is to contribute to the investigation of epileptogenesis. The study is divided in three parts. The first part investigates possible mechanisms of inherited epileptogenesis in the epileptic mutant mouse tottering (tg/tg) by examining the following questions: 1) The function of cholinergic …
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Paired Pulse Electrical Stimulation In Human Intractable Focal Epilepsy
… identification of synaptic changes related to epileptogenesis in patients investigated with intracranial recordings during presurgical assessment.<br/><br/>HYPOTHESIS: The following hypotheses were tested:<br/>1. Suppression, depression or facilitation is related to seizure onset area.<br/>2. …
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
… the neuronal plasticity changes associated with epileptogenesis. It also provides a practical model to study pharmacological agents that may be useful in preventing or treating epilepsy.
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Assessing the role of the hippocampus in amygdala kindled fear : an analysis of environmental habituation
… used to study the mechanisms involved in epileptogenesis, with long-term amygdala kindling providing a useful model of the behavioural disturbances— such as heightened anxiety— that can occur between epileptic seizures. The purpose of this thesis was to determine whether increased fear …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… improved. Therefore, studying the mechanisms of epileptogenesis is significant to develop better treatments or cure for epilepsy patients. Many patients with neurological disorders suffer from an imbalance in neuronal and circuit excitability and present with seizure or epilepsy as the common …
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Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
… properties involved in the mechanisms of epileptogenesis and induction of seizures, to guide a rational search for such future treatments. In the present thesis, we have applied optogenetics to study these questions, a technology based on modified microbial membrane channels or pumps that …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
… which could be relevant for understanding epileptogenesis in infectious and inflammatory causes of epilepsy.
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Neuromodulation in Experimetal Animal Models of Epilepsy
… seizures evolving from true, genetically-driven epileptogenesis. Genetic absence epilepsy rats from Strasbourg (GAERS) have inborn absence epilepsy and Fast rats have a genetically determined sensitivity for electrical amygdala kindling, which is an excellent model of temporal lobe epilepsy. Our …
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Dynamics and precursor signs for phase transitions in neural systems
… with potential consequences for understanding epileptogenesis. Guided by dynamical systems theory this thesis captures evidence for precursor signs of phase transitions in neural systems using mathematical and computer-based modelling as well as in vitro experiments.
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Microelectrode Array Modeling of Genetic Neurological Disorders in the Era of Next Generation Sequencing
… profiles. MiRNAs are increasingly linked to epileptogenesis. We show that small differences in miRNA expression can have large effects on network activity. Chapter two offers a proof-of-principle of the utility of the CNN-MEA paradigm in capturing pathogenic hyperexcitability. </p><p>Chapter …
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In vitro ηλεκτροφυσιολογική μελέτη των μηχανισμών διαφοροποίησης μεταξύ διαφραγματικού και κροταφικού ιπποκάμπου ως προς την παθογένεση της επιληψίας, την συναπτική ευπλαστότητα και τη δικτυακή ρυθμογένεση
Η λειτουργική διαφοροποίηση κατά το διαφραγματοκροταφικό άξονα του ιπποκάμπου αφορά και την επιληψία. Χρησιμοποιώντας το μοντέλο ελεύθερο μαγνησίου και δυναμικά πεδίου παρατηρήσαμε πως οι επιληπτόμορφες εκφορτίσεις παρατηρούνταν πιο συχνά, είχαν μεγαλύτερη συχνότητα, διάρκεια και ένταση στις …