Global ETD Search
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Showing 1 to 3 of 3 for “"Epigenome editing"”.
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Creation of Versatile Cloning Platforms for Transgene Expression and Epigenome Editing and Their Application to Pancreatic Islet Biology
<p>Insulin secreting β-cells within the pancreatic islets of Langerhans are vital to maintaining glycemic control. β-cell functional mass is lost during the progression to both Type 1 and Type 2 diabetes mellitus, resulting in hyperglycemia. Therefore, a major goal of diabetes research is to …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… enhancer histone acetylation by CRISPR-mediated epigenome editing was sufficient to increase Fos mRNA expression both under basal conditions and following membrane depolarization in primary hippocampal neurons, via a mechanism that involves enhancer recruitment of Brd4, increased transcriptional …
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The design, characterization, and application of CRISPR-based tool in human cells
Many human diseases are associated with dysregulated gene expression. A subset of these diseases arise from deviated functional protein expression from homeostatic regimes. Either not enough, or too much, functional protein expression can cause toxic accumulation of metabolites, dysregulate …