Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 107 for “"Epigenome"”.
-
Understanding the epigenome using system genetics
… in a human population to reconstruct the human epigenome. Each of the molecular assays is associated with each of the other assays to discover phenotype-to-phenotype correlations. Furthermore, QTL data are used to dissect the causality for these phenotype-to-phenotype correlations in a system …
-
Rearrangements of 7q11.23: disorders of the epigenome
… the impact of rearrangements at 7q11.23 on the epigenome, I have studied parent-of-origin dependent expression of individual genes at this locus, as well as genome-wide DNA methylation. Here I provide the first evidence to show that rearrangements of 7q11.23 result in dose-dependent changes to …
-
The Effects of Cannabis sativa on the Sperm Epigenome
… investigate the effects of cannabis on the sperm epigenome as use increases across the globe. Further, it is critical to investigate these effects on genes that are uniquely positioned to contribute to early development. The hypothesis of this research was that cannabis exposure is associated with …
-
Bioinformatic methods for analyses of epigenome and RNA interactome
The sequenced genetic codes for multiple species have provided great sources for understanding how a single genome can give rise to a complex organism. However, only a small percent of mammalian genome could be identified as protein-coding genes. Our understanding of the genome is far from …
-
Investigating the impact of pharmacological exposures on the developing epigenome
… of the impact of exposures on the developing epigenome and presents imprinted genes as sensitive barometers for detecting alterations to the epigenome during development.
-
Investigating DNA G-quadruplex structure function through genome and epigenome engineering
… cellular context. Using CRISPR genome and epigenome engineering, I performed a series of genetic and epigenetic perturbations in human cells to specifically modulate G4 formation within the upstream regulatory region of the *MYC* oncogene. In combination with chromatin profiling, …
-
Understanding machine learning models of the epigenome with statistics and statistical mechanics
Epigenetic changes are chemical and structural modifications of DNA and its associated proteins which do not change DNA sequence. These modifications mark and package DNA in different ways and help to establish cell types, which are distinct and heritable gene expression states. Understanding …
-
THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
Epigenetic reprogramming and chromatin structure guide differentiation and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated …
-
Activin/Nodal Signalling Controls the Epigenome and Epitranscriptome of Human Pluripotent Stem Cells
… and differentiation by shaping both the epigenome and the epitranscriptome of hPSCs. Secondly, it provides a novel powerful technology to facilitate further studies of the mechanisms that regulate cell fate decisions.
-
Exposures and the Impacts on the Epigenome that Persist from Youth to Adulthood and Intergenerationally
Environmental exposures have an impact on the epigenome that persists throughout a lifetime and can be transmitted intergenerationally. While a plethora of exposures exist, the mechanisms of epigenetic destruction are unique with each exposure. My research explores two exposures, arsenic and the …
-
The role of MLL4 in the chromatin framework: from the epigenome to 3D genome organization
MLL4 is a histone methyltransferase of the Trithorax (TrxG) group, crucial for maintaining active gene expression by antagonizing Polycomb (PcG) proteins, which enforce repressive states. Proper TrxG-PcG crosstalk is critical for various cellular processes and for determining cell fate. Although …
-
Miniaturised epigenome and interactome screening : development and application of microfluidic ChIP-seq and AP-MS
Contains fulltext : 213664.pdf (Publisher’s version ) (Open Access)
-
Using Advanced In Vitro Models to Investigate the Adverse Effects of Methotrexate on the Developing Epigenome
… the effect of pharmaceutical drugs on the epigenome has come to light with more novel drugs being designed to target the epigenome. The epigenome is vital for successful development, therefore, it is important to understand the risk of exposure to current and novel drugs during pregnancy …
-
Microhabitat, microbiota, mitochondria and the epigenome shape the biparental legacy of heat exposure in a tropical arthropod
As technology and policy advance towards sustainable energy sources, humanity is reaching a critical climax regarding climate change. Average global surface temperatures have risen by 1oC since pre-industrial levels, and it is estimated that temperatures will continue to rise by at least 1.5oC …
-
The impact of chronic loss of STAG2 on DNA damage repair and the epigenome in acute myeloid leukaemia
… elucidated. In addition, it is likely that the epigenome is affected by Cohesin’s involvement in chromatin compaction and transcriptional regulation, however, this has not previously been explored in the literature and how a STAG2 mutation would impact the epigenome is unknown. Therefore, the …
-
The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
The remarkable advancements in sequencing technologies have allowed the entire mutational landscape of hundreds of different types of human cancers to be defined. This knowledge gives patients two new categories of treatment options, small molecule inhibitors and targeted immunotherapy. Veterinary …
-
Creation of Versatile Cloning Platforms for Transgene Expression and Epigenome Editing and Their Application to Pancreatic Islet Biology
<p>Insulin secreting β-cells within the pancreatic islets of Langerhans are vital to maintaining glycemic control. β-cell functional mass is lost during the progression to both Type 1 and Type 2 diabetes mellitus, resulting in hyperglycemia. Therefore, a major goal of diabetes research is to …
-
Alterations in the Hippocampal Epigenome as a Result of Alcohol Exposure During the Perinatal Period of Development in Rats
… ethanol exposure alters the hippocampal epigenome in juvenile rats in a sex-specific manner. A three trimester model of ethanol exposure was used in which pups were exposed to ethanol throughout gestation and from postnatal days (PD) 2 to 10 (ET group). Control groups included rats …
Page 1 of 6