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Showing 1 to 8 of 8 for “"Epigenetic therapy"”.

  1. Epigenetic therapy based on micrornas inhibition for the amelioration of masld phenotype

    Montero-Vallejo, Rocío2024

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most prevalent liver disorder worldwide. In Europe, around 25% of people suffer from this disease. It is strongly associated with several comorbidities, including obesity, type 2 diabetes mellitus, and metabolic …

    sevilla Repository record

  2. Epigenetic Therapy of Lung Cancers: Anti-tumoral effect of valproate on small cell lung cancer

    Hubaux, RolandULiège - Université de Liège2011

    Lung cancer is the leading cause of cancer-related death worldwide. Among lung carcinomas, the outcome of small cell lung carcinoma (SCLC) patients is the poorest of any histological subtype with five-year survival rate of less than 20 and 5 % for limited and extensive stage respectively. Based on …

    liege Repository record

  3. EPIGENETIC THERAPY FOR FRIEDREICH’S ATAXIA: A PHASE 1, FIRST IN MAN, ASCENDING DOSE CROSSOVER STUDY TO INVESTIGATE THE SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF RG2833 (A HISTONE DEACETYLASE INHIBITOR) IN ADULTS WITH FRIEDREICH’S ATAXIA

    Clerico, Marinella, De Mercanti, Stefania FedericaUniversità degli Studi di Torino2018

    unito Repository record

  4. Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

    Zhang, HanghangTemple University. Libraries2017

    … we discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression and cell differentiation, along with activation of endogenous retrovirus (ERV) genes. CDK9 inhibition results in dephorphorylation of the SWI/SNF protein …

    temple Repository record

  5. Epigenetic silencing of gene expression in paediatric astrocytoma

    Kardooni, Hoda2015

    … children. Despite advances in surgery and chemotherapy, brain tumours are still the main cause of cancer deaths in children. Furthermore, little is known about DNA methylation changes in paediatric astrocytoma. Recent investigations suggest that many tumours are initiated not only by genetic …

    wlv Repository record

  6. Targeting Unique Domains of Lsd1 Regulates Pediatric Glioma Innate Immunity and Nk Cell Metabolism

    Bailey, Cavan, <p>0000-0003-2334-2612</p>2021

    … DNA template. Cancers will often hijack these epigenetic pathways, reactivating developmental genes to drive growth and deactivating tumor suppressor and immune recognition genes. Chromatin-modifying proteins deposit and remove chemical moieties from histone tails to aid in governing gene …

    uthsc Repository record

  7. AI Assisted Cellular and 3D Spheroid Analyses for Combined Therapies Against Glioblastoma

    Amoah, IsaacCreighton University2025

    … survival of only 15 months despite maximal therapy. While combination therapies involving radiation with immunotherapies, epigenetic therapies, molecularly targeted therapies, etc., show promise, current methods for evaluating whether combination therapies work are slow, need extensive …

    creighton Repository record

  8. Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1

    Hsu, Chen-IVirginia Tech2025

    Epigenetic events refer to heritable changes in phenotypes that occur without alterations in the underlying DNA sequence. Among the major layers of epigenetic control, methylation of histone H3 at lysine 36 (H3K36) and lysine 27 (H3K27) defines euchromatin and facultative heterochromatin, …

    vt Repository record