Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Epigenetic factors"”.
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Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates
… At the crossroads of fate-switching, pioneer factors are a class of transcription factors equipped to bind cognate motifs in closed chromatin. Once they access the closed chromatin, pioneer factors can either act as transcriptional activators or repressors of cell fates by recruiting …
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The role of epigenetic factors in the pathogenesis of familial X-linked mental retardation (XLMR)
Mental retardation (MR) is a handicap with severe implications not only for thosethat suffer from this disability, but also for their families, society and the welfaresystems which support them. A large proportion of these individuals are afflictedwith the X-linked form of the condition. To date a …
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Date with Destiny: Genetic and Epigenetic Factors in Cell Fate Decisions in Populations of Multipotent Stem Cells
… to explore the effects of chromatin-associated factors on the ability of pluripotent mouse Embryonic Stem Cells (ESCs) to self-renew, via monitoring gene expression heterogeneity of key genes. The second model focused on Neural Mesodermal Progenitors (NMPs), a bipotent cell population found in …
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Asymmetry and discordance in Carabelli's trait and the hypocone: do MZ and DZ twins point to common underlying epigenetic factors?
… and MZ twin discordance suggest there are factors at work beyond genes that moderate crown trait expression, suggesting the possible action of common, underlying epigenetic mechanisms.This study looks beyond the classic "genetically controlled" paradigm of nonmetric crown tooth traits by …
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Computational Approaches to Predict Effect of Epigenetic Modifications on Transcriptional Regulation of Gene Expression
… to infer protein-DNA bindings in the presence of epigenetic modifications. Epigenetic modifications are alterations to the DNA resulting in gene expression regulation where the structure of the DNA remains unaltered. It is a heritable and reversible modification and often involves addition or …
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DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
… for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and …
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Biomarkers: Implications from Discovery and the development of Microscale Electrochemical Sensing Techniques for Their Detection
… to molecular biology, is with regard to the epigenetic mechanisms associated with aging. This work was carried out in association with the Wang lab at the University of Louisville, School of Medicine. In this study a review of known epigenetic factors that influence aging or age-related …
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PU.1-ACTIVATED GENOMIC REGIONS DEFINE LOW-RISK MDS SUBSETS CHARACTERIZED BY IMMUNE DYSREGULATION AND DISEASE PROGRESSION
… Collectively, these findings identify epigenetic factors that predispose low-risk MDS patients to progression into high-risk MDS and, ultimately, sAML. Moreover, they provide proof of concept for targeting PU.1 as a potential strategy to prevent disease progression in low-risk MDS.
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The Effects of Chromatin Remodeling and Pseudokinase Activity on Liver Pathophysiology
… not completely understood, specific genetic and epigenetic factors that drive aspects of this pathophysiology can shed further light on both how these diseases develop and on how normal, healthy regeneration differs from liver disease. In this body of work, we show that loss of Arid1a, a …
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The ultrastructural morphology of Eimeria tenella exhibits striking natural variation and undergoes significant changes during the first few hours of infection
… cell morphometry; this could be due to genetic/epigenetic factors or may reflect an undiscovered maturation phase. The conoid is a cytoskeletal structure found in many important apicomplexan pathogens and is involved in host cell invasion and parasite motility. I have performed the first high …
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The role of galectin-3 and galectin-9 in the chronic inflammation of rheumatoid arthritis
… Galectin-3 expression seemed to be controlled by epigenetic factors (methylation) but not cytokine stimulation. Galectin-9 production was up-regulated by interferon-y, interleukin-1b and ligands for Toll-like receptors 3 (TLR3) and 4 (TLR4). It was found that intracellular presence of galectin-9 …
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Derivation and Comparison of Androgenic and Gynogenic Monoploid Potato Families
… may differ due to gametic selection and/or epigenetic factors. Our objectives were to derive androgenic and gynogenic monoploid populations from each of two diploid (2n = 2x = 24) Solanum phureja clones and compare their phenotypic characteristics in a greenhouse study. A haploid-inducing …
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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma
… regulatory interactome and identified multiple epigenetic factors including HDACs and KDM1A. We determined that inhibitors to both HDACs and KDM1A, which often form complexes together, reduce TCF4 protein stability. Our work suggests that loss of TCF4 protein expression is an important …
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Prevalence of visual impairment and severity of diabetic retinopathy in various ethnic groups in the UK
… the prevalence of DR, VI and associated risk factors for sight threatening diabetic retinopathy (STDR) in Afro-Caribbeans (AC) and South Asians (SA) compared to Caucasians. People with diabetes in two regions in the United Kingdom who were screened and/or treated for DR from September 2008 to …
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Multiscale Genomic Analysis of the Corticolimbic System: Uncovering the Molecular and Anatomic Substrates of Anxiety-Related Behavior
… genetic, environmental, experiential, and epigenetic factors. </p> <p>The work presented in this dissertation is a multi-scalar, integrative analysis of the molecular and neuroanatomic substrates that underlie emotion-related behavior. The amygdala is a principle component of the limbic …
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Maternal Modulation of Neonatal Immunity
… immaturity. Results support the hypothesis that epigenetic factors (maternal immune reactions during gestation) can modulate maturation of an immune cell repertoire and development of cytokine response capabilities in offspring.</p>
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UNRAVELLING THE MOLECULAR BASIS OF ALZHEIMER¿S DISEASE AND FRONTOTEMPORAL DEMENTIA: GENETIC AND EPIGENETIC APPROACH THROUGH NEXT GENERATION SEQUENCING AND OPENARRAY TECHNOLOGIES
… the multifactorial aetiology of the disorders. Epigenetic and environmental factors interplay to influence this complexity. The aim of the present project was to explore the two most common forms of dementia using genetic and epigenetic approaches. The first part focused on the genetic screening …
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Relationships between chromatin features and genome regulation
… features (e. g. CpG) can attract transcription factors (TFs) and influence chromatin structure or RNA polymerase II (Pol II) binding, initiation and elongation; (2) non-sequence, epigenetic factors - histone modifications, TF binding, chromatin remodelling (histone placement, eviction and …
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