Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Epigenetic clock"”.
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On the epigenetic ageing clock in humans
Epigenetic clocks are mathematical models that predict the biological age of an organism using DNA methylation data, and which have emerged in the last few years as the most accurate biomarkers of the ageing process. However, little is known about the molecular mechanisms that control the rate of …
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Applying molecular methods to investigate potential anthropogenic impacts on ageing in a free-living bat species
… sites was measured to develop and validate an epigenetic ageing model for M. bechsteinii. A CpG-based epigenetic clock was constructed using 12 biomarkers from four genes and evaluated using leave-one-out cross-validation, demonstrating accurate within-sample age prediction. Although the model …
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MULTI-ORGAN FAILURE DRIVEN BY TELOMERE UNCAPPING
The telomere-bound shelterin complex safeguards chromosome ends from being recognized as DNA double-strand breaks, a function mostly dependent on TRF2. Loss of TRF2 results in telomere uncapping, activation of the DNA damage response, and chromosomal end-to-end fusions, with dramatic consequences …