Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"Epigenetic Regulation"”.
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
… that expression of DAX-1 may be governed by epigenetic mechanisms. </p> <p>We sought to determine whether promoter region CpG island methylation and expression of DAX-1 were inversely related , and if the loss of DAX-1 expression in the breast cancer cell line MCF-7 is due to epigenetic …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
Epigenetic mechanisms are of fundamental importance for resolving and maintaining cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
Accurate regulation of gene expression is critical for normal brain function. Many human neurodevelopmental and neurodegenerative disorders are associated with mutations in genes important for controlling transcription. Mutations in one such gene, the transcriptional repressor methyl-CpG-binding …
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Characterising the MLL complex: epigenetic regulation of Hoxa genes
… and its associated complex contribute to gene regulation in a functionally relevant cell background. To assess dynamic processes involved, we developed a haematopoietic Stem Cell (hSC) -based system, in which Hoxa genes are down-regulated in a differentiation- induced manner. I characterised …
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Mechanical and epigenetic regulation of cell plasticity and tumorigenicity
Made available in DSpace on 2015-09-29T21:08:15Z (GMT). No. of bitstreams: 2 SINGH-THESIS-2015.pdf: 283696 bytes, checksum: 0f7e963da95634dafa16e9e9a970da45 (MD5) LICENSE.txt: 4208 bytes, checksum: dd735d55c1189c6cc1ef21be4dc1ab2c (MD5) Previous issue date: 2015-07-22
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Epigenetic regulation of neuroinflammation in the aged mouse brain
… suggesting that they are a likely target for epigenetic regulation. In order to determine possible causes and targets for interventions to promote healthy aging, the current dissertation explored the role of epigenetic regulation in microglia as well as potential pharmacological and dietary …
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Epigenetic Regulation Controls Intrinsic and Extrinsic Drivers of Gastrointestinal Development
… gene expression patterns in the early gut. Epigenetic control of gene expression offers a possible mechanism for orchestrating the necessary gene expression patterns, but very little is known about how epigenetic forces regulate gut development. In this thesis, I first investigated how …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
… restraint on proliferation (via Cyclin D1 downregulation) and survival (via BIM induction) may indicate how BRD4 inhibition is exquisitely effective against MPNSTs and may represent a paradigm shift in therapy for MPNST patients. Moreover, these findings indicate an epigenetic mechanism …
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
… this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. Jumonji domain containing proteins demethylate tri- and dimethylated histone lysines and regulate …
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Epigenetic Regulation of Replication-Dependent Histone mRNA 3 End Processing
CDK9, eine cyclin-abhängige Ser/Thr-Kinase, phosphoryliert die C-terminale Domäne der größten RNA Polymerase II (RNAPII)-Untereinheit an Serin 2. Diese posttranslationale Modifikation reguliert die Aktivität der RNAPII im Anschluss an die Transkriptionsinitiation. Darüber hinaus wird CDK9 ebenfalls …
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EPIGENETIC REGULATION IN AN IPSC-NEURON MODEL OF FAMILIAL ALZHEIMER’S DISEASE
… and tau neurofibrillary tangles in the brain. Dysregulation of epigenetic histone modifications may lead to the expression of transcriptional programs that may play a role in disease genesis or the worsening of disease pathology. One such histone modification, acetylation of histone H3 lysine …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
<p>Over the past two decades, epigenetic regulation has become a rapidly growing, highly innovative and influential field of biology and medicine. Protein acetylation and deacetylation, two key epigenetic regulatory mechanisms, are mediated by histone acetylase transferases (HATs) and histone …
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Structural Basis Of Epigenetic Regulation And Protein Scaffolding In Development And Diseases
… have determined their mechanisms of action in epigenetic regulation and protein scaffolding, respectively. </p> <p>Primarily identified as a histone lysine methyltransferase, SMYD2 has been shown to be play important roles in muscle development and tumorigenesis. In addition to histone …
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Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
… requires precise coordination between epigenetic programming and transcriptional regulation. In this thesis, I present my findings on two epigenetic regulatory complexes Chd7/Sox10 and lncOL1/Suz12 in CNS myelination and remyelination. First, we show that chromatin remodeler Chd7 is …
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Epigenetic Regulation of Neurogenesis in Non-Demented Humans with Alzheimer’s Disease Neuropathology
… to investigate the role of neurogenesis and its epigenetic regulation by microRNA in the preservation of cognition against Alzheimer’s disease. This was accomplished by comparing by immunohistochemistry the capacity for neurogenesis in the subgranular zone of the hippocampus in 4 distinct …
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The role of Polycomb-mediated epigenetic regulation in embryonic stem cell differentiation
… this process? Polycomb group (PcG) proteins are epigenetic regulators necessary for proper differentiation of cells and for mammalian development. Notably, faulty regulation of PRC2 has been associated with a broad range of cancers, suggesting that it has a critical role in maintaining cell …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
Epigenetic regulation of gene expression plays essential roles in controlling normal cellular functions as well as abnormal cellular activities in human diseases like inflammatory diseases and cancers. The bromodomain-containing protein 4 (BRD4), one of the BET (bromodomain and extra terminal) …
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EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… shows that the microglial PI3K/AKT pathway is epigenetically regulated through miRNA targeting by miR-21-5p and histone modifications via HDAC3 resulting in changes in PI3K expression, the phosphorylation of AKT and the cAMP response element binding protein (CREB) and ultimately brain-derived …
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