Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Epigenetic Modulators"”.
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Mutant Kras Alters Extracellular Vesicle Microrna Sorting In Pancreatic Cystic Neoplasms
… years, EV microRNAs (miRNAs) small, noncoding, epigenetic modulators of gene expression, have been of interest due to their well-documented role in cancer.</p> <p>Herein, we demonstrate that mutations in <em>KRAS</em> are associated with alteration to the EV miRNome in a cell line disease …
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Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites
… they should bind to essential proteins, such as epigenetic modulators. Here we aimed to evaluate if PROTACs (MZ1 and VZ185) targeting epigenetic mechanisms have activity against P. falciparum parasites and if they are active due to a unique MoA. Both PROTACs were found to be active against the …
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Pharmacological Inhibition of LSD1/KDM1A in Diffuse Midline Glioma Models and Impact on Kinase Signaling
… H3K27 mutation. Recent publications, highlight epigenetic modulators as promising cancer-specific targets emphasizing their potential as a novel therapeutic strategy. Epigenetic modulator, lysine specific demethylase 1 (LSD1) is a histone demethylase. It’s function demethylates mono- and …
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DEVELOPING CHEMICAL TOOLS TO MAP MOLECULAR MECHANISMS THAT DRIVE DISEASE
… post-translational modifications on proteins and epigenetic DNA modifications, which can have pronounced effects on cell function and can be equally damaging if not properly regulated. Understanding how molecular events influence health is of paramount importance in designing therapeutics that …
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The Effects of Methyltransferase Genes on Human Haematopoietic Stem Cell Function
… genes, PRMT5 and DNMT3A, which are both epigenetic modulators of HSC function. Pharmacological inhibition of PRMT5 in healthy human cord blood (hCB) haematopoietic stem and progenitor cells (HSPCs) leads to reduced HSPC proliferation and a relative differentiation block at the CD34+ …