Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Epidermal homeostasis"”.
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… study investigated the role of PRC2 in human epidermal homeostasis and hair growth. The expression of EZH2 was elevated in differentiating suprabasal layers of the human epidermis. Consistently, EZH1/2 expression and enzymatic activity was upregulated in differentiating primary human …
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Transcriptional functions of the corepressor Sin3A in skin
Upon activation in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell …
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Regulation of apoptosis and desmosomes by RhoE
… Although the precise mechanism by which epidermal homeostasis is regulated is still far from clear, much progress has been made in the characterisation of signaling pathways involved in normal epidermal function. A key group of signaling proteins that have been clearly implicated in …
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The role of translation in keratinocyte cell fate determination.
… eventually shed off, helping to maintain tissue homeostasis. Cultured human keratinocytes generate a range of colony sizes, but can be separated into two groups based on the ratio of outcomes after cell division. On average, ‘balanced’ colonies give rise to equal numbers of proliferative and …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… between keratinocytes and immune cells disturbs epidermal homeostasis resulting in hyperproliferation and loss of differentiation. Recently, short (~22 nt) genetic molecules called microRNAs (miRNA) that regulate gene expression by repressing messenger RNA (mRNA) have gained attention as robust …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
<p>Epidermal homeostasis is paramount for the ongoing function of the skin as the primary barrier between a mammalian organism and the external environment. Homeostasis is achieved through a complex and delicate balance of cell death, cell proliferation and cell differentiation. Critical for …