Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Epidermal growth factor receptors"”.
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… cancer (CRC). Among these molecular targets is Epidermal Growth Factor Receptors (EGFRs) which are overexpressed in cancer cells. Targeting and blocking the downstream signaling could lead to cease cell proliferation and division and hence control the spread of the disease. Molecular modeling is …
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Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
… through overexpression and/or activation of the epidermal growth factor receptors EGFR/ErbB1 and Her2/ErbB2 and defects in the apoptotic program. The development of therapeutic resistance is a significant barrier to successful treatment in IBC, and thus, strategies targeting the mechanisms that …
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Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy
… exploitation as therapeutic targets. Human epidermal growth factor receptors (HERs) and NF-E2-related factor 2 (NRF2) are regulators of cellular proliferation and determinants of cancer initiation and progression. NRF2 and HERs confer cancers with resistance to several therapeutic agents. …
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A functional analysis of Rab11a and Rab11b in endosomal recycling
… Rab11b differentially regulate protein levels of Epidermal Growth Factor Receptor (EGFR), Her2 and E-cadherin. Furthermore, a number of other observations indicating that Rab11a and Rab11b have distinct cellular roles have been observed. Together these suggest that Rab11a and Rab11b have …
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Unraveling the intricacies of spatial organization of the ErbB receptors and downstream signaling pathways
… to determine if 'receptor-sharing' occurs when receptors are clustered. In our proposed 'receptor-sharing' mechanism a cytosolic species binds with a receptor then disassociates and rebinds a neighboring receptor. We tested our hypothesis using a novel computational approach, the ACGMC, an …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… that cross talk between G protein-coupled receptors and Epidermal Growth Factor Receptor (EGFR) is critical for steroidogenesis in all three major steroid-producing tissues. We have recently characterized the intracellular signals regulating Luteinizing Hormone (LH) -induced steroid …