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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 118 for “"Epidermal growth factor receptor (EGFR)"”.

  1. Epidermal Growth Factor Receptor(EGFR) als mögliches neues Therapieziel bei vielen Tumortypen : Einfluss von Nachweisverfahren auf Bedeutung und Logistik

    Kury, Christian

    … auf Amplifikation und Überexpression des EGFR-Gens bzw -Rezeptors mittels Microarrays. Die Überexpression wurde mit 3 verschiedener Antikörper nachgewiesen, die das gleiche Target "EGFR" hatten.Zusätzlich wurde untersucht wie Amplifikation und Überexpression miteinander …

    freiburg-diss Repository record

  2. Molecular testing for predictive purposes of epidermal growth factor receptor (EGFR) gene mutations in advanced Non Small Cell Lung Cancer (NSCLC) patients

    Piva, Roberto, Di Bello, CristianaUniversità degli Studi di Torino2019

    unito Repository record

  3. Clinical and molecular features of Epidermal Growth Factor Receptor (EGFR) mutation positive non-small-cell lung cancer patients treated with tyrosine kinase inhibitors: predictive and prognostic role of co-mutations

    Scagliotti, Giorgio Vittorio, Novello, Silvia, Bussolino, Federico, Bironzo, PaoloUniversità degli Studi di Torino2021

    unito Repository record

  4. Tyrosine 370 Phosphorylation of Atm Positively Regulates Dna Damage Response

    Lee, Hong-Jen2015

    … ATM associates with and is phosphorylated by epidermal growth factor receptor (EGFR) at Y370 at the site of double-strand breaks. Depletion of endogenous EGFR impairs ATM-mediated foci formation, homologous recombination, and DNA repair. Moreover, ATM Y370F mutant or pretreatment with an EGFR …

    uthsc Repository record

  5. Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance

    Liao, Hsin-Wei2016

    <p>Protein modifications of epidermal growth factor receptor (EGFR) intracellular domain are well known regulators of EGFR functions whereas those of its extracellular domain remain relatively unexplored. Here, we report that methylation at R198 and R200 of EGFR extracellular domain by protein …

    uthsc Repository record

  6. Mechanisms Underlying Distinct Egfr Versus Fgfr-3 and -1 Dependency In Human Bladder Cancer Cells

    Cheng, Tiewei2015

    <p>The epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) are activated by gene amplification, mutation and overexpression in bladder cancer, which drives tumor development and progression. Both EGFR and FGFR inhibitors are currently being tested in clinical …

    uthsc Repository record

  7. Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme

    Johnson, Blake P2015

    … understood. Since activating mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in GBM, we examined whether EGFR could induce Fyn expression. Here, we found that wild-type EGFR, and to a greater extent hyper-activating EGFR mutants, EGFRΔIII and R108K, induce a …

    uthsc Repository record

  8. Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB

    Fraser, Tyler Malcolm2018

    … (UV) radiation from the sun is the most dominant factor contributing to tumor initiation and progression. The condition is most prevalent in populations with lighter skin and older age. Current pharmaceutical molecular research targets the inhibition of the Epidermal Growth Factor Receptor (EGFR), …

    calpoly Repository record

  9. Mechanotransduction via airway epithelial cells : the effect of compressive stress

    Kojić, Nikola, 1978-Massachusetts Institute of Technology2007

    … minutes resulted in transient activation of the epidermal growth factor receptor (EGFR) - MAP kinase (ERK) signaling pathway. Furthermore, specialized real-time high-speed imaging revealed an exponential decrease in the volume of the compliant lateral intercellular space (LIS) separating …

    mit Repository record

  10. Epidermal growth factor receptor in equine gastric stratified squamous mucosa: effect of progressive ulceration on receptor density

    Jeffrey, Stuart C.Virginia Tech1996

    … here was to document the distribution of epidermal growth factor receptor (EGFr) and quantitate receptor density in normal as well as ulcerated equine gastric squamous mucosa. Fifteen horses with endoscopically normal stomachs were divided into three equal groups. Group 1 was a normal …

    vt Repository record

  11. The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway

    Kafaei Shahbaz, Naz2022

    … decreases in a commonly altered pathway called Epidermal Growth Factor Receptor (EGFR) protein signalling pathway. Together, these results demonstrate that with further research, GM2A may serve as a therapeutic target to halt breast cancer metastasis.

    queens Repository record

  12. Dissecting The Molecular Mechanism of Early Tumor Dissemination In Non-Small Cell Lung Cancer

    Liu, Xingtong, <p>https://orcid.org/0000-0002-1161-7976</p>2020

    … evidence, underline mechanisms and risk factors for the NSCLC relapse remain largely unknown. Addressing these questions will be critical for the development of strategies to stratify the risk of recurrence and approaches to reduce these risks. My thesis focused on dissecting the …

    uthsc Repository record

  13. The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway

    Bharath, RanjeethaMassachusetts Institute of Technology2015

    … the various downstream components of the epidermal growth factor receptor (EGFR) pathway. This work develops a mathematical model that consists of partial differential equations and signaling networks. Analysis techniques for these nonlinear reaction-diffusion equations included a study of …

    mit Repository record

  14. A functional analysis of Rab11a and Rab11b in endosomal recycling

    Artemiuk, Patrycja A.University College Cork2019

    … Rab11b differentially regulate protein levels of Epidermal Growth Factor Receptor (EGFR), Her2 and E-cadherin. Furthermore, a number of other observations indicating that Rab11a and Rab11b have distinct cellular roles have been observed. Together these suggest that Rab11a and Rab11b have …

    cork Repository record

  15. Innovative Methods for Outcome-Based Pricing of Treatments from the US Payer Perspective (The Six Delta Platform)

    Alkhatib, NimerThe University of Arizona.2020

    … of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation.

    arizona-thes Repository record

  16. Development of mass spectrometry based technologies for quantitative cell signaling phosphoproteomics : the epidermal growth factor receptor family as a model system

    Wolf Yadlin, AlejandroMassachusetts Institute of Technology2007

    Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by dynamic phosphorylation on a multitude of pathway proteins. Quantitative features, including intensity, timing, and duration of phosphorylation of particular residues play a role in determining cellular …

    mit Repository record

  17. Characterization of split ends function during Drosophila eye development

    Doroquez, David BagonMassachusetts Institute of Technology2007

    … cell fate specification, differentiation, and growth. Rather than functioning as completely independent modules, signaling pathways interface to create a web of specific interactions that a cell integrates in a spatial and temporal manner. The Epidermal Growth Factor Receptor (EGFR) and Notch …

    mit Repository record

  18. Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases

    Yang, Rob2010

    The epidermal growth factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are …

    wustl Repository record

  19. Pancreatic Ribonuclease Functions As An Epidermal Growth Factor Receptor Ligand Independently of Its Enzyme Activity and Contributes to Cetuximab Resistance

    Lee, Heng-Huan2015

    … suspected to have an unidentified cell surface receptor. Epidermal growth factor receptor (EGFR), a well-characterized receptor tyrosine kinase is an effective therapeutic target in multiple cancer types. However, clinical trials targeting EGFR have not demonstrated improved therapeutic efficacy …

    uthsc Repository record

  20. Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer

    Yam, Clinton, <p><a href="https://orcid.org/0000-0002-0809-0851?lang=en" target="_blank">https://orcid.org/0000-0002-0809-0851</a></p>2020

    … Notably, we found that c-MET interacts with the epidermal growth factor receptor (EGFR) in PARP inhibitor-resistant triple-negative breast cancer cells, potentially explaining the limited effect of c-MET depletion alone on talazoparib sensitivity. Together, these data suggest that the combination …

    uthsc Repository record

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