Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"Epidermal growth factor (EGF)"”.
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Structural Determinants in the folding of epidermal growth factor (EGF)-Like domains
The epidermal growth factor (EGF)-like domain is an evolutionarily conserved modular protein subunit. Despite hypervariability of amino acid sequences in their inter-cysteine region, they preferentially fold into a three-looped conformation with a disulfide pairing of C₁-C₃, C₂-C₄, C₅-C₆. To …
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Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking
… human breast cancer cells require an AREG/EGFR autocrine loop for cell proliferation. We also demonstrated that AREG can increase EGFR stability and promote EGFR localization to the plasma membrane. In the presented dissertation we successfully knocked-down AREG expression in SUM-149 cells …
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The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… to the cell membrane. Currently, the effect of growth factors such as epidermal growth factor (EGF) on ion transport in the airway has not been previously researched and is consequently unknown. Therefore the aim of this thesis is to determine (i) if EGF has an effect on ion transport in the …
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Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
… have long been sought after in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor inhibitors (EGFRIs)), of using …
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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines ©
The receptor activator of nuclear factor-kB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The …
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An injectable gelatin-based conjugate incorporating EGF promotes tissue repair and functional recovery after spinal cord injury in a rat model
… injected as a liquid. Gtn-HPA incorporating epidermal growth factor (EGF) and/or stromal cell-derived factor - 1ɑ (SDF-1ɑ) was evaluated for promoting tissue healing and functional recovery using a standardized 2-mm hemi-resection SCI rat model, four weeks after injection. Injection of …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
… the early molecular mechanisms involving epidermal growth factor (EGF) binding and EGF receptor (EGFR) dimerization are not as well understood. Due to the large disparity of time and length scales involved in receptor dimerization reactions, we adapt the coarse-grained Monte Carlo (CGMC) …
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An injectable, biomaterial-based therapy to promote endogenous neural progenitor cells in a hemorrhagic stroke lesion
… acid, Gtn-HPA) incorporating epidermal growth factor (EGF) to increase the number of endogenous nestin-positive neural progenitor cells (NPCs) in the lesion. In a well-validated intracerebral hemorrhagic (ICH) stroke model in rats, NPCs were quantified and compared to ICH-only …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
Epidermal growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… of MB-derived cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor …
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Polymer-tethered epidermal growth factor as an inductive biomaterial surface for connective tissue progenitors
… However, the response of CTP to most growth factors and cytokines is unknown. Many envisioned applications of CTP, such as treating large defects in bone, involve in vivo implantation of CTP attached to a scaffold, a process that creates an acute inflammatory environment that may be …
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Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition
… profile, over-expression of transcription factors involved in EMT, adhesion to bone marrow endothelium and increased migratory capabilities. Research suggests that transforming growth factor (TGF)-ß and Epidermal Growth Factor (EGF) induces EMT and allows cancer cells to become more …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
At the present time, growth factor stimulation of cell proliferation is conceptualized predominantly in terms of the initial binding event between the growth factor and its receptor. However, the dynamics of the cellular trafficking of growth factors and their receptors can be an important …
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… study investigates the regulatory effects of epidermal growth factor (EGF) on cytokine gene expression in order to determine whether previously published examples of EGF repressing the expression of interleukin 6 (IL-6) mRNA occur in other cell types and whether the effects of EGF are mediated …
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Characterization of Ligand-Induced Conformational Changes in the EGF Receptor
… of ligand-induced conformational changes in the EGF receptor by Katherine S. Yang Doctor of Philosophy in Biochemistry Washington University in St. Louis, 2009 Professor Linda Pike, Chairperson The epidermal growth factor: EGF) receptor is a classical receptor tyrosine kinase that mediates …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
Growth factor signaling can affect tissue remodeling through autocrine and paracrine mechanisms. Recent evidence indicates that hypertrophic signaling in cardiomyocytes is induced through transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… regulated by the steroid hormones and the epidermal growth factor (EGF) family control mammary development are unclear. We have identified the CUB and zona pellucida-like domain containing protein-1 (CUZD1) as a target of estrogen regulation in the mouse mammary epithelium. Mice lacking …
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Rapid Two-Photon Holographic Scan Microscopy with Individual Quantum Dots and Its Applications in Biological Samples
… hologram scan microscopy. The endocytosis of epidermal growth factor (EGF) receptors in breast cancer cells was verified by imaging quantum dot labeled fixed cell sample with the technique. The strong colocalization of EGFR and HGFR (c-Met) in the same clusters in EGF/HGF stimulated breast …
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Development of a collagen gel sandwich hepatocyte bioreactor for detecting hepatotoxicity of drugs and chemicals
… 50,000 cells/cm2. We also evaluated the need for epidermal growth factor (EGF) in our cultures, by comparing urea and albumin secretions in cultures grown with and without EGF. The cultures without EGF had significantly less secretion of both urea and albumin just two days after plating. …
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