Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 618 for “"Epidermal"”.
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Biosignal acquisition for epidermal electronics
Amplifiers for biomedical applications have been a subject of study for more than a century. However, it was not until this last decade that amplifiers that conform to the skin mechanics were introduced. The introduction of such a class of electronics brings along technical challenges from the …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation and proliferation in response to ultraviolet (UV) irradiation, resulting in …
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Exploring the diversity of epidermal pavement cell shapes
… absent in others, like Brachypodium distachyon. Epidermal cell patterning is qualitatively similar between individuals of the same species but different species can have wildly different shapes and there is no comprehensive data set available for epidermal cell shapes. Moreover, the cell shape …
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MicroRNA-184: A Multifaceted Regulator of Epidermal Keratinocyte Biology
… between keratinocytes and immune cells disturbs epidermal homeostasis resulting in hyperproliferation and loss of differentiation. Recently, short (~22 nt) genetic molecules called microRNAs (miRNA) that regulate gene expression by repressing messenger RNA (mRNA) have gained attention as robust …
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Epidermal Reactions to Injury with Implications for Innate Immunity
… peptides (AMPs) in the skin mediated by the epidermal growth factor receptor (EGFR) transactivation process. In paper II we further highlight the importance of this mechanism by demonstrating that it is responsible for the bulk of the expression of the AMPs known to be induced in epidermis …
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Investigating Differentiation: A Role for Organelle Inheritance in Epidermal Growth
… growth and differentiation in the context of epidermal development, where populations of stem cells are maintained in careful equilibrium and induced to proliferate and differentiate in response to stimuli such as injury or cyclical growth signals. During development, a naïve epidermis …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… complex to the cell cortex of cultured epidermal cells. In addition, I found that interaction with LGN is necessary but not sufficient for cortical NuMA recruitment. This led me to examine the role of additional NuMA-interacting proteins in spindle orientation. Notably, I identified a …
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Characterizing and engineering antibodies against the epidermal growth factor receptor
Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to receptor overexpression, mutation, or autocrine ligand has been observed in a wide …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… the mechanisms behind oncogene tolerance during epidermal development, a time of significant physiological tissue expansion, has not been explored. This is exemplified in RASopathies, where patients rarely develop epidermal defects or cancers despite germline mutations in the RAS/MAPK signaling …
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Design and applications of antibody mimics against epidermal growth factor receptor
<p>Antibodies have been widely used as reagents, homing devices, diagnostics and as therapeutic agents against different targets in clinic and research. Recently a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great …
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The Symptom Experience of Patients Receiving Epidermal Growth Factor Receptor Inhibitors
… the symptom experience of patients receiving epidermal growth factor receptor inhibitors (EGFRIs) for breast, colon, head and neck, and colon cancer. EGFRIs are targeted therapies used at various points along the treatment continuum for these solid tumors, and may be first, second or …
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
<p>Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. …
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Comparison of Epidermal and Dermal Fingerprints Collected from Thiel-embalmed Bodies
Direct comparison of dermal and epidermal fingerprints can be vital to the identification of bodies where the epidermal skin layer is no longer available for fingerprinting. It has been reported that identification based on the comparison between dermal and epidermal fingerprints is possible, …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… by overexpression and/or mutation of the epidermal growth factor receptor (EGFR). Also common to this subtype of GBM is the loss of crucial tumor suppressor genes Ink4A/ARF and PTEN, which contribute to the invasive nature and unregulated proliferation that underlie the GBM pathology. The …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… processes. In skin, MYC induces the exit of epidermal stem cells from their niche, increases proliferation of progenitor cells and subsequently stimulates lineage specific differentiation into interfollicular epidermis and sebaceous glands; yet the direct transcriptional roles of MYC in these …
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Epidermal growth factor and Transforming growth factor α motogenic activities are mediated by Epidermal growth factor receptor : Identification of signalling pathways involved in head and neck cancer
<b> Background</b>: The alteration of Epidermal Growth Factor Receptor (EGFR) plays a major role in the development of Head and Neck cancer. However, the only FDA approved EGFR target for this neoplasm is the drug Cetuximab. Cetuximab can only be used where there is an over-expression of EGFR. …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
… the early molecular mechanisms involving epidermal growth factor (EGF) binding and EGF receptor (EGFR) dimerization are not as well understood. Due to the large disparity of time and length scales involved in receptor dimerization reactions, we adapt the coarse-grained Monte Carlo (CGMC) …
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