Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"EphA5"”.
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
… been found to antagonize the interaction between EphA5 and its ligands with high selectivity. EphA5 receptor and its ligands serve as repulsive axonguidance cues in the developing brain. Their interaction triggers growth cone collapse and inhibits the neurite outgrowth in vitro. Furthermore, …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… with myelin to promote macrophage clearance. EphA5 has been shown to be upregulated in various RNA sequencing data sets and can induce contact dependent migratory behaviour within cells. EphA5-EphrinA signalling as a potential mechanism to induce macrophage migration and efflux out of the …
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TOWARDS RETINA REGENERATION: THE EPIGENETIC BASIS OF NEURONAL AND AXON GUIDANCE GENE REGULATION
… determining gene Atoh7 and axon guidance genes EphA5 and EphB1 in Müller glia derived spheres were investigated prior to and following demethylation. Bisulfite sequencing (BS) showed that in ImM10 spheres, the promoters of these genes exhibited a high frequency of methylation and quantitative …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… of the brain. The axonal guidance receptors EphA5 and EphA6 are expressed in gradients across the retina, and changes in their expression alter the location of retinal ganglion cell (RGC) synaptic termination zones. Therefore, new RGCs will need to express EphA5 and EphA6 at levels …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… GCs stimulated with recombinant ephrin-A5 or EphA5 exhibit reduced cell spreading or adhesion, respectively, indicating a cell-autonomous response to Eph-ephrin stimulation. In order to ascertain the importance of ephrin-A5 in female fertility, we performed a reproductive assessment of females …