Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"EphA4"”.
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Characterization of cofilin and its potential role in the EphA4 pathway
<p>EphA4 is a receptor tyrosine kinase that is responsible for cellular adhesion and locomotion using repulsion signaling in early development of <em>Xenopus laevis</em>. EphA4 regulates cellular locomotion by controlling proteins within its signal transduction pathway, which may include the …
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Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… been evaluated. Initial findings suggest the EphA4, a well-established axonal growth and guidance receptors, plays a novel role in LMC arteriogenesis. This dissertation examined PDIC-specific functions of EphA4 using GFP labeled bone marrow chimeric mice subjected to permanent middle cerebral …
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Influence of Peripheral Immune-Derived EphA4 on Microglial Dynamics Following Traumatic Brain Injury
… to retool their activation state in the brain. EphA4 receptor tyrosine kinase has been identified as a potential cell-to-cell contact protein on PICs that could be involved in the inflammatory changes following TBI. While microglial activation changes have been described in TBI models, the …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… following injury has identified endothelial EphA4 receptor tyrosine kinase as a major regulator of vascular regrowth. The research outlined herein utilizes an endothelial-specific EphA4 knockout mouse model (KO-EphA4flf/Tie2-Cre) to determine the extent to which this receptor may influence …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… intervention. Our preliminary studies, in an EphA4 global knockout mouse model, indicated that EphA4 receptor tyrosine kinase severely limits pial arteriole collateral formation. The preliminary work also showed that activation of EC EphA4 receptor in vitro inhibited vascular formation. …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
… and in tumorigenesis. The activation of EphA4 receptors in the frog, <em>Xenopus laevis</em>, causes loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that these receptors achieve their cellular effects at least in part by inhibiting RhoA GTPase. …
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EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
An astonishing number of deaths and related disabilities are attributed to traumatic brain injury (TBI) in the United States per year. Due to the unforeseeable nature of TBI and its association with the sequelae of other neurological comorbidities, research is centered around the secondary …
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Novel Immune-Regulatory Mechanisms in a Mouse Model of Traumatic Brain Injury
… a novel role for the tyrosine kinase receptor EphA4 in the peripheral-derived immune response to brain trauma. Previous work has demonstrated significant differences in recovery from TBI in young vs adult animals, and some studies have indicated that the immune response contributes to these …
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Therapeutic Targeting of Arteriogenesis Following Ischemic Stroke
… arteriogenesis. Previous research has revealed EphA4 restricts arteriogenesis through the Tie2 signaling axis, therefore this work sought to evaluate the endothelial cell (EC) specific role of the EphA4/Tie2 axis in acute arteriogenesis. EC-specific EphA4 KO mice displayed increased pial …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… of a1-chimaerin with its known effector EphA4, and potentially with other undefined membrane proteins, in a C1-domain- dependent manner. In addition, my results show that a1-chimaerin associates via its NTD with the Src kinase Fyn, and via its C1 domain with the NR2A subunit of the NMDA …
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A Single Cell and Spatial Transcriptomic Investigation of Traumatic Brain Injury: Novel insights into endothelial-derived Eph signaling
… and protein expression of ephrin receptor A4 (EphA4), a well-established axon guidance molecule, within hours and days following TBI. This study is the first comprehensive investigation of the role of endothelial cell-specific EphA4 in TBI on regulating the BBB using advanced techniques like …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… fate at high yield. RNAi knockdown of EphA3, EphA4, and EphA7, was used to identify which Eph receptor was contributing to the apoptotic effect individually. It was found that transient knockdown of EphA3 and EphA4 fail to cause changes in apoptosis levels. However, knockdown of EphA7 at …
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Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury
… identified endothelial cell (EC)-specific EphA4 receptor as a key mediator of aberrant neurogenesis. Taken together, we conclude that increased aberrant neurogenesis contributes to learning and memory deficits after repetitive mild TBI.
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… effector of the axon guidance receptor EphA4, in the assembly of neuronal locomotor circuits in the mouse. Furthermore, I identified two novel neuronal GAPs, mSYD-1A and mSYD-1B, which interact with components of the presynaptic active zone and which may contribute to presynaptic …
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Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
… and EphA2 gene expression, and also increased EphA4 expression. To date, only reperfusion has been shown to reduce injury and improve long-term remodeling. We have discovered two new mechanisms by which this can be effected: 1) we have observed a dramatic reduction in cardiac injury in mice …
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KSHV Susceptibility and Transmission Within Tonsillar Specimens
… we demonstrate that the expression of EphA2, EphA4, and EphA7 are donor and subset-specific and gH/gL-EphA interactions are important for KSHV-WT infection of primary tonsil lymphocytes. These interactions are critical for establishing KSHV-WT infection of plasma cells and germinal center …