Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"EphA2"”.
-
Role and Regulation of Epha2 In Pancreatic Cancer
… was to investigate the role and regulation of EphA2, a receptor tyrosine kinase expressed in PDAC, to further understand this disease and identify new therapeutic targets. The role of EphA2 was determined in PDAC by siRNA mediated silencing. In combination with gemcitabine, silencing of EphA2 …
-
Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
<p>EphA2, also known as ECK (epithelial cell kinase), is a transmembrane receptor tyrosine kinase that is commonly over-expressed in cancers such as those of the prostate, colon, lung, and breast. For breast cancers, EphA2 overexpression is most prominent in the ER-negative subtype, and is …
-
EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… behaviour. Of the majority of Eph receptors EphA2 is overexpressed in many cancers and in PDAC as well. A wealth of literature has reported an increased expression of PLK1 but therapeutic targeting has not been beneficial and hence an alternative strategies are required to treat PDAC …
-
The impact of EPHA2 polymorphism on KSHV infectivity and KS prevalence among HIV/AIDS patients in South Africa
… been elucidated and highlights Eph Receptor A2 (EPHA2) as a specific host receptor for virus entry. Furthermore, EPHA2 has been implicated in oncogenesis and is upregulated in a number of cancers including KS. We therefore hypothesised that mutations in the KSHV host receptor's coding region …
-
Characterisation of Kaposi's sarcoma-associated herpesvirus (KSHV)-driven pathology and disease outcome in HIV infected South African patients
… carcinoma (Eph) receptor A2 protein (EPHA2) tyrosine kinase receptor is a promising candidate for studies on genetic variants as it potentially acts on two levels: susceptibility to KSHV infection (being one of the key receptors utilised by KSHV for cell entry and intracellular …
-
Elucidation of the Proteases Responsible for and the Form of Soluble, Monomeric EphrinA1 Released From Cancer Cells
… In a search for novel tumor-specific targets, ephA2 was identified as an up-regulated gene in GBM patients. Further analysis demonstrated the overexpression of the receptor at the protein level in tumor specimens and cell lines while being absent in normal brain, making EphA2 an attractive …
-
Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… screen we identified inhibition of EPHA2, an oncogenic protein specifically associated to poor survival in TNBC patients, to be the top candidate that enhanced EPA cytotoxicity against TNBC and IBC cells. Though functional assays, we identified combination EPA and EPHA2-inhibition to …
-
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
… with ephrinA1-Fc further increased EphA1 and EphA2 gene expression, and also increased EphA4 expression. To date, only reperfusion has been shown to reduce injury and improve long-term remodeling. We have discovered two new mechanisms by which this can be effected: 1) we have observed a …
-
KSHV Susceptibility and Transmission Within Tonsillar Specimens
… we demonstrate that the expression of EphA2, EphA4, and EphA7 are donor and subset-specific and gH/gL-EphA interactions are important for KSHV-WT infection of primary tonsil lymphocytes. These interactions are critical for establishing KSHV-WT infection of plasma cells and germinal …
-
p53 Functional Interactions: the Study of a New Crosstalk with Estradiol Pathway in Transcriptional Responses to Chemotherapeutics
… PCR (qPCR), seven (INPP5D, TLR5, KRT15, EPHA2, GDNF, NOTCH1, SOX9) were confirmed to be novel direct targets of p53, based on responses in stable MCF7 clone cells silenced for p53, or cooperative targets of p53 and ER. Based on exposure to 5-fuorouracil (another genotoxic drug) and …