Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Eph Receptors"”.
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EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
… family of receptor tyrosine kinases, known as Eph receptors, that are important for axon growth and guidance embryonically and early-postnatally have been implicated in brain insults. Previous findings have shown that Eph expression is upregulated at the mRNA and protein level immediately …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
The Eph receptors constitute the largest family of receptor tyrosine kinases, with 16 individual receptors that are activated by 9 different ephrins throughout the animal kingdom. Eph receptors and their ligands are both anchored to the plasma membrane, and are subdivided into two subclasses (A and …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… hormone (LH) that triggers ovulation. Ephrins (Efn genes) and Eph receptors (Eph genes) are membrane-associated signaling molecules that mediate communication at sites of cell-cell contact, and have been extensively studied in the context of embryonic development. The published …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
<p>Eph receptors and their ligands, ephrins, have been implicated in many important developmental processes and in tumorigenesis. The activation of EphA4 receptors in the frog, <em>Xenopus laevis</em>, causes loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that …
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Mechanisms of Eph/ephrin mediated cell-cell communication
Eph receptors and their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of …
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… metastatic behaviour. Of the majority of Eph receptors EphA2 is overexpressed in many cancers and in PDAC as well. A wealth of literature has reported an increased expression of PLK1 but therapeutic targeting has not been beneficial and hence an alternative strategies are required to treat …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… system development at single cell resolution. Eph receptor tyrosine kinases and their ephrin ligands play a critical role during in vivo cortical development, particularly during axon guidance. Preliminary data has shown that EphRs and ephrins are expressed during in vitro differentiation. In …
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EPH-B and Ephrin-B Signaling in Migration and Proliferation of Stem Cells
In this dissertation, I investigate the role of Eph-ephrin signaling in the Dentate Gyrus (DG). The DG is a distinctive neuronal structure located in the hippocampus and is one of two areas in the mature brain where stem and progenitor cells reside to continuously produce new neurons throughout …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… stress. Finally, Chapter 5 analyzes the role Eph/ephrinB signaling in pancreatic development. Mice lacking signaling of EphB2 and EphB3 receptors showed fewer insulin-producing cells, abnormal islet distribution, anomalies in vasculogenesis and disrupted epithelial polarity and branching. In …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
Eph receptors are transmembrane RTKs that are activated by clustering that occurs on binding to membrane-tethered ephrin ligands. Two members or the ephrin family, ligand ephrinB2 and receptor EphB4 are known for their ability to distinguish arterial versus venous endothelium upon their expression …
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Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
… that intramyocardial administration of ephrinA1-Fc at the time of MI would promote cardiomyocyte survival, subsequently reducing infarct size and inflammatory cell infiltrate. The ephrinA1 ligand has been predominantly characterized as a pro-angiogenic factor in development and tumor …
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The role of EphrinA for the retinotopic map formation in mouse visual cortex
… in axonal guidance and map formation are the ephrin ligands and their Eph receptors. These molecules have been shown to contribute to topographic mapping in several mammalian brain systems including the retinotectal and retinogeniculate projection. Much less is known about mechanisms that are …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
Eph receptors and their membrane-bound ligands, ephrins, provide key signals in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding retinal ganglion cell (RGC) axons from the retina to the right targets in …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… visual areas of the brain. The axonal guidance receptors EphA5 and EphA6 are expressed in gradients across the retina, and changes in their expression alter the location of retinal ganglion cell (RGC) synaptic termination zones. Therefore, new RGCs will need to express EphA5 and EphA6 at levels …