Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Eph"”.
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Eph-mediated restriction of cerebrovascular arteriogenesis
… intervention. Our preliminary studies, in an EphA4 global knockout mouse model, indicated that EphA4 receptor tyrosine kinase severely limits pial arteriole collateral formation. The preliminary work also showed that activation of EC EphA4 receptor in vitro inhibited vascular formation. …
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Mechanisms of Eph/ephrin mediated cell-cell communication
Eph receptors and their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
Eph receptors and their membrane-bound ligands, ephrins, provide key signals in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding retinal ganglion cell (RGC) axons from the retina to the right targets in …
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EPH-B and Ephrin-B Signaling in Migration and Proliferation of Stem Cells
In this dissertation, I investigate the role of Eph-ephrin signaling in the Dentate Gyrus (DG). The DG is a distinctive neuronal structure located in the hippocampus and is one of two areas in the mature brain where stem and progenitor cells reside to continuously produce new neurons throughout …
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Eph Ehly, all-state choir conductor : a video presentation of his philosophy and rehearsal techniques
Dr. Eph Ehly is one of the most sought after choral conductors in the United States today. Ehly has conducted over seventy All-State choirs. However, no previous source outlines the fundamental principles of his philosophy and rehearsal techniques.This study was designed to capsulize Ehly's …
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
<p>Eph receptor tyrosine kinases and their ephrin ligands are required for multiple aspects of nervous system development including axon outgrowth, synaptic plasticity, and the formation of topographic maps in the visual system. The <em>Caenorhabditis elegans </em>ephrin-A, <em>efn-4</em>, has a …
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A Single Cell and Spatial Transcriptomic Investigation of Traumatic Brain Injury: Novel insights into endothelial-derived Eph signaling
… shown increased mRNA and protein expression of ephrin receptor A4 (EphA4), a well-established axon guidance molecule, within hours and days following TBI. This study is the first comprehensive investigation of the role of endothelial cell-specific EphA4 in TBI on regulating the BBB using …
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EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… metastatic behaviour. Of the majority of Eph receptors EphA2 is overexpressed in many cancers and in PDAC as well. A wealth of literature has reported an increased expression of PLK1 but therapeutic targeting has not been beneficial and hence an alternative strategies are required to treat …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… hormone (LH) that triggers ovulation. Ephrins (Efn genes) and Eph receptors (Eph genes) are membrane-associated signaling molecules that mediate communication at sites of cell-cell contact, and have been extensively studied in the context of embryonic development. The published …
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EphA4 Influences Blood Brain Barrier Disruption and Endothelial Cell Response following Traumatic Brain Injury in a Mouse Model
… family of receptor tyrosine kinases, known as Eph receptors, that are important for axon growth and guidance embryonically and early-postnatally have been implicated in brain insults. Previous findings have shown that Eph expression is upregulated at the mRNA and protein level immediately …
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Modeling of equilibrium point trajectory control in human arm movements
… concept of the Equilibrium Point Hypothesis (EPH) is that the CNS provides a virtual trajectory of joint motion, representing spacing and timing, with actual movement dynamics being produced by interactions of limb inertia, muscle viscosity and speed/position feedback from muscle spindles. To …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
The Eph receptors constitute the largest family of receptor tyrosine kinases, with 16 individual receptors that are activated by 9 different ephrins throughout the animal kingdom. Eph receptors and their ligands are both anchored to the plasma membrane, and are subdivided into two subclasses (A and …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… stress. Finally, Chapter 5 analyzes the role Eph/ephrinB signaling in pancreatic development. Mice lacking signaling of EphB2 and EphB3 receptors showed fewer insulin-producing cells, abnormal islet distribution, anomalies in vasculogenesis and disrupted epithelial polarity and branching. In …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… system development at single cell resolution. Eph receptor tyrosine kinases and their ephrin ligands play a critical role during in vivo cortical development, particularly during axon guidance. Preliminary data has shown that EphRs and ephrins are expressed during in vitro differentiation. In …
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Novel Non-Repulsive Outcomes From Ephrin-B Reverse Signaling
… roles for reverse signaling through B-subclass ephrins during embryonic development. The stereotypical outcome of Eph-ephrin signaling has long been established as one of cell-cell repulsion, elicited through a localized breakdown of the actin cytoskeleton. In contrast to this dogma, I have …
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Cerebral spasticity modeled as disorded equilibrium point control
… knee motion. The Equilibrium Point Hypothesis (EPH) of motor control theorizes that the central nervous system (CNS) provides a virtual trajectory of joint motion, representing space and time. A forward dynamic model has been developed that can reproduce kinematic data through the using …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
<p>Eph receptors and their ligands, ephrins, have been implicated in many important developmental processes and in tumorigenesis. The activation of EphA4 receptors in the frog, <em>Xenopus laevis</em>, causes loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that …
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El paradójico crecimiento argentino en 2022
… de datos la Encuesta Permanente de Hogares (EPH) se realizó un análisis cuantitativo para identificar los cambios sectoriales, ocupacionales y condiciones laborales que podrían repercutir en la pobreza y el crecimiento económico. Los principales hallazgos del trabajo arrojan que el aumento de …
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Factores asociados a las diferencias salariales a nivel regional en Argentina
… diferencias salariales utilizando datos de la EPH para el periodo 2016-2019. Específicamente, se explora si dicho diferencial entre aglomerados está asociado a la presencia de economías externas de localización y de urbanización, y la dotación de recursos naturales. Los resultados muestran que …
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Educar para incluir: la formación superior como política laboral. Trayectorias formativas y laborales de jóvenes beneficiarios del programa PROG.R.ES.AR en la ciudad de Mar del Plata (2014-2021)
… públicos, de la Encuesta Permanente de Hogares (EPH), y de entrevistas en profundidad a quienes fueron beneficiarios en la ciudad de Mar del Plata- Batán. Los resultados concluyen en que se ha generado una mejor calidad de oportunidades en esos jóvenes durante sus trayectorias en la universidad, …
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