Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Ependymoma"”.
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Novel Diagnostics and Therapeutic Approaches for Supratentorial Ependymoma
Ependymoma is the third most common paediatric brain tumour. These tumours are incurable in up to 40% of cases. Previously classified as a single disease by histological criteria, ependymomas are now grouped into nine molecular subgroups, three in each compartment of the central nervous system. The …
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Developing Novel Models and Therapeutics for ZFTA-RELA Ependymoma
… cause of cancer related death in children. Ependymomas are the third most common brain tumour in children. These tumours are found to be incurable in 40% of cases, in large part because of a lack on new treatments. Thirty percent of all ependymomas occur in the supratentorial region, of …
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UNDERSTANDING THE CELLULAR AND GENE-REGULATORY MECHANISMS UNDERLYING THE MESENCHYMAL TRANSITION OF EPENDYMOMA TUMOR CELLS USING OMICS APPROACHES
Childhood ependymoma is a cancer of the central nervous system with a chronic relapsing pattern. With little evidence that adjuvant chemotherapies extend patient survival, surgical resection followed by radiotherapy remains the best treatment for this disease. In children, the most common and …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… the majority of which are glial cell tumors (ependymoma and astrocytoma) thought to arise from multipotent neuroglial progenitor (stem) cells (NPCs) within the spinal cord. Whereas many spinal ependymomas exhibit indolent behavior, the only treatment option for clinically-symptomatic tumors is …
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Molecular Mechanisms of C11orf95 translocations in cancer.
… the genetic driver of supratentorial (forebrain) ependymomas as translocations of the C11orf95 gene of unknown function and RELA, the canonical nuclear effector of NF-B signalling. Subsequent studies have reinforced our original findings on the frequency (>70%) of these C11orf95-RELA (C11-RELA) …
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Bypassing the Blood-Brain Barrier: Cucurbit[8]uril-based Hydrogels Towards Drug Delivery Reservoirs
… towards delivery devices in glioblastoma and ependymoma are outlined and discussed. The second chapter focuses on the preparation of peptide-functionalised hyaluronic acid hydrogels dynamically crosslinked using the macrocylic host molecule cucurbit[8]uril (CB[8]). The host facilitates …
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Exploring the Potential use of TEAD Inhibition as Part of a Combination Therapy for NF2-Deficient Schwannoma and Meningioma.
… in the development of schwannoma, meningioma and ependymoma tumours. Although surgical resection and adjuvant radiotherapy can be used, new avenues of therapeutic development are essential to target inoperable and recurrent tumours. Previous studies evaluating small molecule TEAD …
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Ependymal tumours in childhood: outcomes and prognostic factors
… outcomes of paediatric patients treated for ependymoma at our institution. STUDY DESIGN AND METHODS: 51 eligible patients were treated between 1980 and 2013. The median age at presentation was 6 years. The majority of patients were male (66,7%), had infratentorial tumours (62,7%) and had …
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Patient-derived and xenograft-derived organoids for characterization, drugs testing and biobanking of pediatric brain tumors
… PDOs from a variety of pediatric brain cancers (ependymoma, medulloblastoma and low-grade glial tumors) that recapitulates the cellular heterogeneity, histological features, and mutational profiles of the corresponding parental tumors. We have obtained promising results from the DNA methylation …
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The Potential of CRL4-DCAF1 and KSR1 as Therapeutic Targets in Low-grade Merlin-Deficient Tumours
… formation, including schwannoma, meningioma and ependymoma. These tumours can occur sporadically or as part of the genetic condition Neurofibromatosis type 2 (NF2) and cause significant morbidity. The current treatment options are restricted to surgery and radiotherapy, which are invasive and may …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… tumours, primarily schwannoma, meningioma and ependymoma. NF2 is characterised by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations of the encoding gene NF2 or by loss of heterozygosity. These tumours can occur either sporadically or as part of the NF2 condition. The …
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Untersuchungen zur differenzialdiagnostischen Bedeutung des IgG-Index und Albuminquotienten bei neurologisch erkrankten Hunden
… IgG indices was obtained in a patient with an ependymoma. Patients with disc prolapse showed in 8% of the cases a mild increase in IgG index and in 14% a mild increase in albumin quotient, but never a combination of both. In dogs with orthopedic diseases, two (10%) had a slight increase in CSF …
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Immunhistologische und morphometrische Untersuchung der Ependymome im Kindesalter in Korrelation zu den klinischen Befunden
In der vorliegenden Arbeit wurden der klinische Verlauf der Tumorerkrankung von 40 Kindern, die an einem Ependymom erkrankten, erfasst und 58 Tumorproben mittels immunhistochemischer Methoden untersucht. Im Mittelpunkt dieser Untersuchungen standen die Überprüfung der p53-Akkumulation, der …