Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Epac2"”.
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A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… from each of its two main isoforms, EPAC1 and EPAC2, is unclear. Here I test the hypothesis that both EPAC1 and EPAC2 play a key role in the maintenance of persistent nociceptor hyperexcitability and chronic pain after SCI.</p> <p>Using both a T9 SCI mouse model and a T10 SCI rat model, we …
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The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
… exposure. The current results identify IL-6 and EPAC2 as novel mediators of defective hypothalamic glucose sensing, suggesting they may contribute to the development of blunted CRR observed with recurrent hypoglycaemia exposure.
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are relatively unclear. To investigate the integrated metabolic functions of …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are relatively unclear. To investigate the integrated metabolic functions of …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating cAMP effects in various cellular contexts remains relatively unclear, and must be elucidated to examine the therapeutic potential of these proteins. This work investigated the role of EPAC1 in promoting invasion and …
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Regulation of glucagon secretion from pancreatic alpha cells
… by activation of the low-affinity cAMP sensor Epac2 as well as PKA. In addition to PKA, protein kinase C (PKC) was also found to be involved in the regulation of glucagon secretion from both human and murine α-cells. Inhibition of PKC using a pharmacological antagonist suggested that tonic …