Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Eosinophilic esophagitis"”.
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Aspects on the management of patients with eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. …
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The Pathophysiology of Eosinophilic Esophagitis: Altered Mechanisms of Antigen Detection in the Esophagus
… the esophagus has emerged, which is now known as eosinophilic esophagitis (EoE). Incomplete knowledge regarding the pathogenesis of EoE has limited treatment options. EoE is known to be a Th2-type immune-mediated disorder. Based on previous studies in both patients and experimental models, it is …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… inflammation and also in human patients with eosinophilic esophagitis and asthma. Thus, miR-21 is a clinically relevant biomarker for Th2-type pathologies. Our results define a key function for Bcl6 in repressing Gata3 function and miR-21 expression in Tregs, and provide greater understanding …
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Noncanonical NF-KB in Gastrointestinal Disease
… tract, namely a novel model of the disease eosinophilic esophagitis. Our studies revealed that loss of NF-KB-inducing kinase (NIK), the bottleneck molecule in noncanonical NF-KB signaling, results in targeted esophageal inflammation, remodeling, and gene expression changes that are …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… inflammatory diseases of the gut, including Eosinophilic Esophagitis (upper GI tract), Celiac Disease/Non-Celiac Gluten Sensitivities (small intestine), Inflammatory Bowel Disease (entire intestine/large intestine), and an inflammatory subtype of colorectal cancer being Colitis-Associated …
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Integrated, single-cell analysis of transcriptional phenotype and clonotypic identity
… blood of patients with the allergic disease eosinophilic esophagitis (EoE) with scRNA-seq. We identify a clonally expanded, pathogenic effector Th2 (peTH2) cell phenotype that is associated with EoE. This phenotype demonstrates features of an antigen-specific T cell response, including …
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Investigating mitochondria alterations in esophageal pathologies
… is perturbed in esophageal diseases, including eosinophilic esophagitis (EoE), an emerging food allergy and immune-mediated inflammatory disorder, and esophageal squamous cell carcinoma (ESCC), an aggressive malignancy associated with poor patient outcomes. Roles for esophageal epithelial cells …