Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Eosinophilic esophagitis"”.
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The Pathophysiology of Eosinophilic Esophagitis: Altered Mechanisms of Antigen Detection in the Esophagus
… the esophagus has emerged, which is now known as eosinophilic esophagitis (EoE). Incomplete knowledge regarding the pathogenesis of EoE has limited treatment options. EoE is known to be a Th2-type immune-mediated disorder. Based on previous studies in both patients and experimental models, it is …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… inflammation and also in human patients with eosinophilic esophagitis and asthma. Thus, miR-21 is a clinically relevant biomarker for Th2-type pathologies. Our results define a key function for Bcl6 in repressing Gata3 function and miR-21 expression in Tregs, and provide greater understanding …
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Noncanonical NF-KB in Gastrointestinal Disease
… tract, namely a novel model of the disease eosinophilic esophagitis. Our studies revealed that loss of NF-KB-inducing kinase (NIK), the bottleneck molecule in noncanonical NF-KB signaling, results in targeted esophageal inflammation, remodeling, and gene expression changes that are …
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Dysregulation of Noncanonical NF-κB Signaling in Gastrointestinal Diseases
… inflammatory diseases of the gut, including Eosinophilic Esophagitis (upper GI tract), Celiac Disease/Non-Celiac Gluten Sensitivities (small intestine), Inflammatory Bowel Disease (entire intestine/large intestine), and an inflammatory subtype of colorectal cancer being Colitis-Associated …
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Integrated, single-cell analysis of transcriptional phenotype and clonotypic identity
… blood of patients with the allergic disease eosinophilic esophagitis (EoE) with scRNA-seq. We identify a clonally expanded, pathogenic effector Th2 (peTH2) cell phenotype that is associated with EoE. This phenotype demonstrates features of an antigen-specific T cell response, including …
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Investigating mitochondria alterations in esophageal pathologies
… is perturbed in esophageal diseases, including eosinophilic esophagitis (EoE), an emerging food allergy and immune-mediated inflammatory disorder, and esophageal squamous cell carcinoma (ESCC), an aggressive malignancy associated with poor patient outcomes. Roles for esophageal epithelial cells …