Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Eomes"”.
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… of FOXP3+ T regulatory cells (Tregs) and EOMES+ type 1 regulatory T (Tr1) cells, which produce the anti-inflammatory cytokine IL-10, have been identified as key modulators of anti-tumor immunity. IL-10 plays a dual role in cancer, functioning as a checkpoint receptor agonist during …
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Eomes Directs the Formation of Spatially and Functionally Diverse Extra-Embryonic Mesoderm Derived Tissues
… progenitors, is the T-box transcription factor Eomesodermin (Eomes). Eomes is expressed early in gastrulation and plays known roles in various extra-embryonic and embryonic tissues, such as the trophectoderm, visceral and definitive endoderm, and various anterior mesodermal tissues. …
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Molecular definition of group 1 innate lymphoid cells in the uterus
… to the mouse uterus is a population of CD49a+Eomes+ g1 ILCs (trNK), resembling human uNK cells. However, how they relate to uterine Eomes+CD49a- conventional NK cells (cNK) and CD49a+Eomes- ILC1 has been unknown. Determining the function of uterine lymphocytes is challenging because of the …
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THE ROLE OF T-BET IN LUNG INFECTION
… of T-bet and another homologous T-box factor, Eomesodermin (Eomes), in natural killer cells was observed. To further understand immunomodulatory mechanisms of T-bet, we further explored the regulatory effects of T-bet on Eomes. Together, our results provide the possibility of targeting T-bet …
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The role of lactate in CD4+ T cell differentiation and function
… cells greatly upregulated expression of RUNX3, Eomes, GZMB and Perf-1, whereas L-lactate samples showed a more discreet effect. Lactate addition impacted histone acetylation state and metabolic activities like OXPHOS and glycolysis. However, none of these parameters were responsible for …
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Role of Il-17/Il-17Ra Signaling In The Pancreatic Tumor Microenvironment
… B7-H4 is a negative regulator of T cells through Eomes activation. To further investigate the significance of B7-H4 during tumorigenesis, we generated transgenic mice lacking B7-H4 expression. Transgenic animals with pancreatic KrasG12D activation with global deletion of B7-H4 exhibited delayed …
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Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome
… antigen-specific CD4 T cells knocked out for Eomes showed significantly higher proportion of survival compared to wildtype mice. No significant differences in Eomes expression were observed in Mtb-300 specific, IFN+ CD4 T cells in PBMC from paradoxical TB-IRIS cases compared to controls at …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… by expression of the T-box transcription factor Eomesodermin (Eomes) and the co-inhibitory receptor Killer Cell Lectin-like Receptor G1 (KLRG1) which we collectively term ThEO.</p> <p>Herein, we demonstrate that the ThEO phenotype constitutes a stable T cell polarity capable of recalling to …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… cell development such as *Nfil3*, *Runx3* and *Eomes*. Additional putative regulators, such as *Tcf3* (encoding E2A), *Rere*, *Bach1* and *Zfp652* were identified and validated using arrayed CRISPR screens. Due to the known role of *Tcf3*/E2A in the decision between the innate and adaptive …
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In vitro generation and programming of human CD8+ memory T cells
… FoxO1 expression, and an absence of T-bet and Eomes. Collectively, we have established a culture system that enables the exploration of programming events during the priming of naïve human CD8+ T cells that can be further utilized to investigate human CD8+ T cell differentiation and optimal …
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Differential progression of pancreatic premalignancy in geographically distant murine transgenic cohorts uncovers key role of microbial metabolites
… increased levels of T cell exhaustion marker, Eomes. Histological staining confirmed increased expression of Eomes. Taken together these data suggest that within the pancreatic epithelium, IL-17 signaling regulates B7-H4 which can promote T cells exhaustion.</p> <p>In this dissertation we …
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Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
… factors (TFs) such as Zic2/3, Mix-like 1(Mixl1), Eomesodermin (Eomes), Stat3, and Runx1 in early development. These key TFs are involved in a variety of roles, such as metabolism, as well as the fate decision of mesoderm, and blood development. Constructing an understanding of the stepwise role …
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Genesis of the human germline
… competent PreME against rising levels of EOMES. The OTX2 levels continue to increase in ME cells that gain competence for the mesoderm and endoderm fates but are incompetent for germ cell fate. Using the CRISPR toolkit, I further show that SOX17 enhancers are the critical targets of the …