Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 67 for “"Enzyme inhibitors"”.
-
Characterization of Cellulase Enzyme Inhibitors Formed During the Chemical Pretreatments of Rice Straw
… are inhibitory to downstream saccharification enzymes.</p> <p>The saccharification enzyme cocktail is made up of endo-cellulase, exo-cellulase and beta-glucosidase enzymes, whose role is to cleave cellulose polymers into glucose monomers. Specifically, endo-cellulase and exo-cellulase enzymes …
-
The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
Dupuytren’s disease is an acquired condition of the hand associated with fibrosis and contraction of the fascia of the palm, leading to stiffness and inability to properly flex and extend the digits. The disease is caused by both genetic and environmental factors. There is some evidence that …
-
Investigations on Dry Beans (Phaseolus Vulgaris L.): Microstructure, Processing, and Antinutrients (Phytic Acid, Tanning, Enzyme Inhibitors)
The role of microstructure in processing and effects of several processing methods on antinutrients of dry beans were investigated. Proximate composition of whole beans showed minor differences among the ten varieties investigated. Most correlations between selected chemical constituents and …
-
Revealing the Mechanism Underlying the Beneficial Effects of Angiotensin-Converting Enzyme Inhibitors in a Drosophila Alzheimer’s Disease Model
… drugs, including angiotensin-converting enzyme inhibitors (ACE- Is), have been shown to reduce the incidence and progression of AD. However, the literature describing their beneficial effects is inconsistent, with contradictory findings reporting no effects. How these drugs may function …
-
The Activity of Analogs of the Natural Product Dillapiol and Sessamol as Detoxification Enzyme Inhibitors and Insecticide Synergists
… for their potential as cytochrome P450 inhibitors and insecticide synergists. Dillapiol was chosen as a lead compound because it has a methylenedioxyphenyl (MDP) functionality that serves as a cytochrome P450 inhibitor and reported insecticide synergist activity comparable to the …
-
Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure
… two recently developed molecules which have dual enzyme inhibitor activity. Omapatrilat, a molecule which inhibits both angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), and SLV 306 (active metabolite KC12615) a compound with both NEP and endothelin converting enzyme (ECE) …
-
The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review
… fibrotic state. Angiotensin converting enzyme inhibitors (ACEI), which increase Ac-SDKP levels with antifibrotic effects in animal models, are candidate drugs for preventing constrictive pericarditis if they can be shown to have similar effects on AcSDKP and fibrosis in human tissues. …
-
A systematic review of outcomes associated with withholding or continuing angiotensinconverting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARB) prior to noncardiac surgery
… are taking either an angiotensin-converting enzyme inhibitor (ACE-I) or an angiotensin receptor blocker(ARB). The current recommendations whether to continue or withhold ACE-I and ARB in the perioperative period are conflicting. Previous metaanalyses have linked preoperative ACE-I /ARB …
-
The kidney in diabetes mellitus : urinary transfer in excretion, hypertension, the Renin-Angiotensin-Aldosterone system, and the role of angiotensin converting enzyme inhibitors in therapy
… with lisinopril, an angiotensin converting enzyme [ACE] inhibitor, in microalbuminuric and macroalbuminuric diabetic subjects show a reduction in TER independent of reduction in blood pressure. Data are presented suggesting a role for altered renal tubular function in TER in diabetes. The …
-
A study of several factors incident to the absorption of choline from the small intestine of the albino rat
… of choline in the small intestine, or whether enzyme inhibitors might produce an effect on rate of absorption. In view of the possibility that active transport, and thus enzyme activity, might be involved in choline absorption, it is conceivable that rate of choline absorption might be altered …
-
Genetic and biochemical analysis of ACE inhibitor-induced angioedema in black and coloured South Africans
Angiotensin converting enzyme inhibitors (ACEi) are routinely used as first line treatment for hypertensive patients because of their protective effects against heart and kidney disease. Despite their clinical benefits, ACEi used is associated with adverse side effects such as life threatening …
-
Chemical and Enzymatic Synthesis of Dehydropeptides and Their Fluoro Analogs
… mechanism and can be applied to the design of enzyme inhibitors and active site affinity labels. Fluorodehydroalanine has been synthesized from serine in 7 steps with a fluoro-Pummerer rearrangement as the key step. The stereochemical integrity at the alpha-carbon in the fluoro-Pummerer …
-
ABSENCE OF V1AR ALTERS CARDIAC FUNCTION AT BASELINE AND FOLLOWING ACUTE CARDIAC INJURY
… receptor blockers/ARBs or angiotensin converting enzyme inhibitors/ACEi’s) Additionally, clinical studies have demonstrated that drugs blocking these neurohormones from properly signaling have decreased hospitalizations, morbidity, and mortality in these HF patients; and these are the only classes …
-
Clinical assessment of arterial stiffness
… kidney disease (CKD) and angiotensin converting enzyme inhibitors (ACE-Is). A reproducibility study demonstrated good reproducibility. A study of healthy subjects demonstrated a stronger relationship with age for arterial stiffness than intima media thickness (IMT). Case control studies …
-
Potential Natural Product Phosphodiesterase Inhibitors
… investigate the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of …
-
Targeting Telomerase Overexpression by Synthetic Dosage Lethality
… raised the hypothesis that inhibiting this enzyme is a powerful antitumor strategy. Despite intensive research to seek direct enzyme inhibitors, sufficiently potent and specific small-molecule inhibitor has not been fount yet. This suggests that direct targeting of hTERT might not be an …
-
In vivo identification of drug therapeutics for nemaline myopathy
… kinase receptors, and other non-receptor enzyme inhibitors. To test the efficacy of these compounds in a mammalian system, selected candidates will be further screened in Klhl41 mutant C2C12 myoblast cells, bridging the gap between zebrafish models and mammalian systems. This study …
Page 1 of 4