Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Enzyme dynamics"”.
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The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure
… baseline patient characteristics and lactate dynamics in PHLF as well as the predictive value of lactate, INR and bilirubin were determined. Results: Forty-seven patients, mean age 56.5 (±13.2) years, of whom 24 were males were assessed. Five (10.6%) patients had PHLF and were older (67.4 ± …
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Understanding molecular and cellular processes using statistical physics
… systems. In this work, we try to describe the dynamics at both cellular and molecular levels. Microtubule dynamics and dynamic disorder of enzyme proteins are two of the examples we investigated. The dynamics of microtubules and the mechanical properties of these polymers are essential for many …
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A control-theoretic approach to dynamic optimization of metabolic networks
… control principles that underpin metabolic dynamics is an important part of systems analysis in biology. It has been long argued that many biological regulatory mechanisms have evolved so as to optimize cellular adaptation in response to external stimuli. In this thesis we use an optimal …
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Study of the Dynamics of Retaining GT-B Fold Glycosyltransferases Using Hydrogen Deuterium Exchange Mass Spectrometry
… positioning. To achieve this, GT-Bs show global dynamics involvingrigid body rotation between two globular Rossmann domains and likely local dynamics. Toelucidate substrate-induced local dynamics, hydrogen-deuterium exchange mass spectrometry(HDX-MS) is used to analyze CgMshA from Corynebacterium …
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Molecular Design and Mechanistic Characterization of Glycoside Hydrolases using Computational and Experimental Techniques
… activity is due to the activity of multiple enzymes, including endoglucanases, cellobiohydrolases and glucosidases that work synergistically to solubilize crystalline cellulose efficiently. The dependence of hydrolysis reaction rate on temperature predicts that large increases in performance …
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The Dynamics of Dehydrogenases - A Phase Space Odyssey
Enzymes are immensely powerful and efficient heterogenous catalysts which are essential for life. As essential to life as enzymes are, it is still not well understood exactly how they enhance the rate of their catalyzed reactions up to 19 orders of magnitude over their solution phase counterpart …
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COMPUTATIONAL ENZYME ENGINEERING: FROM MOLECULAR MODELING TO MACHINE LEARNING
… of biocatalysis in modern life sciences. Enzymes, as highly selective and efficient natural catalysts, offer significant advantages for environmentally benign and carbon-neutral processes. However, their practical application is often limited by narrow substrate scope, insufficient …
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Conformational Entropy in PEPCK Catalysis: Dynamic Motions Critical to Function
Enzymes increase the rate at which chemical reactions occur. How they achieve this rate increase has been an area of intense research for many years. Multiple studies have shown that dynamic motions of individual protein segments can play a role in enzyme function. Our enzyme of interest, …
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Conserved Conformational Dynamics Control PTP1B Enzymatic Activity
… long-accepted paradigm of biochemistry is that enzyme function depends on the three-dimensional (3D) structure. However, this paradigm is changing. Namely, the emerging view is that protein function also depends on intrinsic protein dynamics. Further, while sequence conservation is …