Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Enzyme activation"”.
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Radiofrequency heating of nanoclusters and nanoparticles for enzyme activation
… concept of local heat, we explored the RF remote activation of a thermophilic enzyme, thermolysin, covalently attached to gold coated iron oxide nanoparticles (6.1 nm in core diameter). Thermolysin activity was a function of applied radiofrequency power, independent of bulk solution temperature. …
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Investigation of the role of the DNA-modifying enzyme, activation-induced cytidine deaminase (AID), in cancer
The DNA-editing enzyme, Activation-Induced cytidine Deaminase (AID) is essential for antibody diversification and plays an important role in immunity. AID is specifically expressed in activated B-cells and mutates targeted DNA sites, diversifying the antibody repertoire. Due to its mutagenic …
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Developing a Plant-Based Vaccine Against the Respiratory Syncytial Virus (Rsv)
… is the result of polygalacturonase (PG) enzyme activation. The fruit-ripening promoter and the terminator regions from PG were sequenced. BLASTn analysis reveals sequence homology to genes involved in ethylene production, pigment synthesis, and transcriptional control.
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Effect of ethanol on hepatic metabolism and enzyme activities
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Production process improvement and characterization of starch nanocrystals
Submitted in fulfillment of the academic requirement for the degree Masters of Applied Sciences in Food Science and Technology, Durban University of Technology, Durban, South Africa, 2023.
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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… antigen specificity. CSR is initiated by the enzyme activation induced cytidine deaminase (AID), which produces nucleotide mismatches in actively transcribed immunoglobulin heavy chain (Igh) switch donor and acceptor DNA. The 3' Regulatory Region (3'RR), a prototypical super-enhancer located …
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PHYSICOCHEMICAL STUDIES ON THE CATALYTIC AND REGULATORY SUBUNITS OF RIBONUCLEOTIDE REDUCTASE FROM CALF THYMUS
… preparation results in a nearly two-fold enzyme activation. The M2 subunit has a UV-visible absorption spectrum with a major peak at 404 nm but this spectrum is different from that of the B2 subunit of E. coli ribonucleotide reductase. This chromophore is also observed in intact calf …
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Micro-analysis of adenylate cyclase and cyclic AMP-dependent protein kinase activities in human mammary tumors
… techniques was used to elucidate the enzyme profiles of adenylate cyclase and cAMP-dependent protein kinase within a series of malignant and benign human mammary tumors. The methods allow for determination of enzyme activity in histologically-confirmed neoplastic areas within …
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Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation
… of G:C base pairs to G:U lesions by the enzyme activation induced cytosine deaminase. Left unrepaired, G:U lesions will give rise to transition mutations at G:C base pairs, but are converted to transition and transversion mutations at G:C and A:T base pairs by the paradoxical …
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Biochemical characterization of calmodulin isoforms and identification of calmodulin-binding proteins in Arabidopsis
… pathways. A combination of in vitro biochemical enzyme activation and molecular biological approaches were employed to tackle this question. First, CaM isoforms produced from E. coli expression systems were used to test their abilities to activate pea NAD kinase. There was a small, but …
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The role of DEAD-box helicase 1 in humoral immune responses
… (DDX1) is implicated in targeting the mutagenic enzyme Activation-Induced Cytidine Deaminase (AID) to Ig loci to initiate CSR. The aim of this project was to interrogate further the role of DDX1 during humoral immune responses, to understand whether DDX1’s impact on B-cell biology extends beyond …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… previous studies showed that both NADPH oxidase enzyme complexes and eNOS localize to endothelial caveolae microdomains. Additionally, caveolae internalization has been shown as an activating mechanism for enzyme eNOS. However, roles of caveolae in ROS/RNS generation and downstream signaling …
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STRUCTURAL STUDY OF HUMAN CATENIN ΒETA-LIKE PROTEIN 1 AND DOUBLE RNA PSEUDOKNOTS IN -1 RIBOSOMAL FRAMESHIFTING
… partner of the antibody-diversification enzyme activation-induced cytidine deaminase (AID) for its nuclear import and subnuclear trafficking. In this dissertation, the crystal structure of full-length human CTNNBL1 is reported. The protein contains six armadillo (ARM) repeats that pack …
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The effect of environmental stress and selective glucocorticoid receptor modulators on chicken and human leukaemia cells
… would potentially dissociate transcriptional activation from repression, minimize the side effects and GC resistance, towards improving childhood leukemia therapy. The recently developed selective GR modulator (SGRM) Compound A (CPDA) and synthetic GC dexamethasone (DEX) were used together …
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Dietary carbohydrates influence the structure and function of the intestinal alpha-glucosidases
… to the enterocyte surface to act as a digestive enzyme. As this finding suggested a maltose sensing ability of small intestinal enterocytes, molecular mechanisms associated with the maturation and trafficking of HMW SI were further investigated. A pulse-chase experiment using [<sup> …
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Comparative Biochemistry of Drug-Binding Proteins in Calmodulin/S100 Family
… binding activity of calmodulin related to its enzyme activator and protein binding activities? In these questions lies the essence of our approach to the molecular aspects of the relationship between the inhibitory drug binding activities and the functional activities of calmodulin. While other …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… nitric oxide synthase (iNOS). AGE-induced enzyme activation and NO production could be blocked by intracellular-acting antioxidants: Ginkgo biloba special extract EGb 761, the estrogen derivative, 17ß-estradiol, R-(+)-thioctic acid, and a nitrone-based free radical trap, …
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An investigation of the impact of the B cell lymphoma factor Activation Induced Cytidine Deaminase (AICDA/AID) on epigenetic plasticity
… genes. The overexpression of the DNA modifying enzyme Activation-induced cytidine deaminase (AICDA) is a factor linked to cancer progression, particularly B-cell derived non-Hodgkin lymphomas, but has also been associated with other inflammation-associated cancers, including colorectal cancer …