Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Enzymatic stability"”.
-
EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… interaction with efflux and influx transporters, enzymatic hydrolysis, and bioavailability. These prodrugs targeting peptide transporters were demonstrated to evade P-gp mediated efflux and exhibit better permeability characteristics compared to APV. All these prodrugs have higher aqueous …
-
Preparation and Characterization of Lyophilized Cyclodextrin Complexes of a Hemisuccinate Ester of Delta-9-Tetrahydrocannabinol for Transmucosal Delivery
… the effect of RAMEB and HPBCD on chemical and enzymatic stability and in vitro permeation across excised buccal mucosa of THC-HS. There was a significant reduction in chemical hydrolysis of complexed prodrug as compared to free prodrug. RAMEB afforded better stability profile and lower …
-
Investigation of Keratin and Keratin-Containing Composite Biomaterials: Applications in Peripheral Nerve Regeneration
… of material properties such as mechanical and enzymatic stability were conducted in addition to observing the differences in solution behavior between products. Data revealed that protein aggregation during the extraction process has a profound effect on keratose hydrogel material properties. …
-
Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
… were determined to be optimum in terms of enzymatic stability, uptake and cytotoxicity. Uptake and docking results indicated that Lvaline in the terminal position increases the affinity of prodrug to the peptide transporter protein. Entrapment efficiency values of L-valine-L-valine-ACV and …