Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 385 for “"Enzymatic Activity"”.
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Conserved Conformational Dynamics Control PTP1B Enzymatic Activity
… techniques, our study shows that the increase in activity of PTP1B is solely achieved through a change in the underlying dynamics. These data demonstrate that within the sequence is conserved the information not only for structure but also dynamics which work together to optimize protein function. …
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Small Molecule Modulation of Caspase Enzymatic Activity
… residue. Small molecule modulation of caspase activity can play an important role in the study of the apoptotic cascade, the role caspases have within apoptosis, and the various diseases that arise from misregulation of apoptosis. These small molecules could also be therapeutically relevant. …
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FRK cancer-related mutations: Effect on enzymatic activity and cellular processes
… the remaining mutants in FRK had no effect on activity. The uncharacterized cancer related mutations of FRK produced interesting results where the mutations in kinase domain (K265R, N359I, del VF) reduced, inactivated and increased kinase activity respectively. Proliferation, migration and …
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Synthesis of Water Soluble Quantum Dots and their Application for Enzymatic Activity Measurements
… PEG and coupling agent EDAC are controlled. The enzymatic activities based on QDs FRET system at different environments was demonstrated and the results show that pH affect the enzymatic activity significantly.
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Investigating green walls for greywater treatment and visualising enzymatic activity in constructed wetlands
L'abstract è presente nell'allegato / the abstract is in the attachment
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Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family
… largely unknown. The well known product of PARP activity is poly(ADP-ribose) (PAR), which is a structurally complex polymer that can be up to 200 units in length. Because the PARP family was identified based on sequence homology to the catalytic domain of PARP1, the founding PARP member and main …
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An investigation into the enzymatic activity of deepsea actinobacteria in decolourising crystal violet dye
… dye decolourisation, biodegradation assays, enzymatic assays, SDS-PAGE, Native PAGE, TLC and LC/MS/MS methods revealed the mechanism involved in the decolourisation of CV. Gordonia sp. JC 51 decolourised CV via enzymatic and non-enzymatic mechanisms. However, true decolourisation of CV was …
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Enzymatic activity of Xylaria digitata ; and, The cultivation of Penicillium pinophilium in nutrient salt solutions
Tests carried out to determine the enzymatic activity of the fungus Xylaria Digitata showed the presence of Diastase, Invertase, Cytase, Maltase, Emulsin and Erepsin. Oxidase, protease and Amidase were not found to be present.
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Removal of refractory contaminants from mature landfill leachate utilizing fungi and evaluation of lignocellulosic enzymatic activity
… fungi and to investigate their lignocellulosic enzymatic activities. Among the six deployed fungal species (Trichoderma asperellum, Cladosporium sp., Penicillium sp., Tyromyces chioneus, Bjerkandera adusta, and Phanerochaete chrysosporium), Penicillium sp. and T. chioneus appeared to be most …
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Activity-Based Protein Profiling Reveals Changes to the Regulation of Enzymatic Activity by the Hepatitis C Virus
… are built, maintained, and controlled by the activity of enzymes. Understanding how enzymes contribute to the regulation of various pathways and processes allows us to gain a deeper understanding of the entirety of the biological system. As changes in enzyme activity are often essential for …
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Non-Enzymatic Activity Of The Alpha Tubulin Acetyltransferase Alpha-Tat1 Differentially Alters The Stability Of Dynamic And Stable Microtubules
… reconstitution experiments revealed that non-enzymatic αTAT1 activity destabilizes dynamic microtubules but does not substantially impact the stability of long-lived microtubules. We propose that the specific suppression of dynamic microtubules by non-enzymatic αTAT activity regulates the …
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Divergent Evolution of Enzymatic Activity: Functional Assignment and in Vitro Evolution in the MLE Subgroup of the Enolase Superfamily
… strategies for the divergent evolution of new enzymatic function, particularly within the context of enzymes containing the ubiquitous (beta/alpha)8-barrel fold. We have used the paradigm of the enolase superfamily and genomic context to functionally assign unknown proteins as L-Ala-D/L-Glu …
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EFFECT OF HISTIDINE TAG ON THE ENZYMATIC ACTIVITY OF PSEUDOLYSIN AND ITS INTERACTION WITH THE STREPTOMYCES METALLOPROTEASE INHIBITOR (SMPI) PROTEIN
… effect of N-terminal Histidine (His) tag on the enzymatic activity of PLN and its interaction with SMPI. His-tagged PLN and SMPI proteins were expressed in bacteria and purified by affinity chromatography and gel filtration. His tag was removed by digestion with tobacco etch virus (TEV) protease. …
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A four-cysteine zinc finger in carboxyltransferase structurally links the functions of enzymatic activity and negative feedback regulation of translation
… that the zinc-binding domain is involved in both enzymatic activity of the enzyme as well as mediating binding of the enzyme to its own subunit mRNA. In this utility, the zinc-binding domain as a structural feature physically links the two functional aspects of the enzyme, possibly as a means to …
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The Evolution of Enzymatic Activity in the Crotonase Superfamily: The Mechanism of the Reaction Catalyzed by 2-Ketocyclohexanecarboxyl-Coa Hydrolase
The stereochemical progress of the reaction catalyzed by BadI is important for understanding the catalytic roles of residues in the active site. It was concluded that, unlike other stereochemically characterized crotonase homologs, this reaction must proceed via a Z-enolate. Based on the …
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Phytoplankton Response to South Louisiana Crude Oil Exposure: Determining Impacts at Individual, Community, Toxin Production, Enzymatic-Activity and Gene-Expression Levels
… GoM at individual, community, toxin-production, enzymatic, and gene-expression levels. At the individual level, phytoplankton size influenced tolerance to crude oil, but taxonomic group seemed to be a more predominant criterion. In general, diatoms showed better tolerance to crude oil than …
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The Effect of The Modification of The Acidic and Zwitterionic Phospholipid Composition on The Enzymatic Activity of D-Beta-Hydroxybutyrate Dehydrogenase
… of the phospholipid composition on the enzymatic activity of D-beta-hydroxybutyrate dehydrogenase (BDH) was examined. Phospholipase D was used to increase the acidic phospholipid composition. This enzyme hydrolyzed primarily zwitterionic phospholipids to phosphatidic acid, an acidic …
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Trypsin Monolayers at the Water-Air Interface. A Study of the Influence of Mode of Formation and of Irradiation Upon Enzymatic Activity
Made available in DSpace on 2015-05-12T17:03:33Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0016378.PDF: 6365592 bytes, checksum: 817fd23837870422f0426461abd28173 (MD5) Previous issue date: 1956
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Understanding the determinants for substrate recognition, regulation of enzymatic activity and the development of broad-spectrum inhibitors of coronavirus 3-chymotrypsin-like proteases
… goal of this project is to investigate enzymatic and structural properties of multiple 3CLpro enzymes encompassing different coronavirus subclasses. Understanding the determinants of structural and functional disparity between different 3CLpro enzymes and the factors regulating these …
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