Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Enz-resistance"”.
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Role of the extracellular matrix-integrin interaction in enzalutamide resistance of bone metastatic castration-resistant prostate cancer
… for 90% of all metastasis incidence. Its resistance to androgen-deprivation therapy (ADT). Enzalutamide (Enz) is a second-generation androgen-receptor (AR) antagonist, developed to treat bone mCRPC by blocking the androgen signalling pathway. However, the emergence of resistance to Enz …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… to recurrent disease occurs in 20-50% of men and resistance to subsequent hormonal therapies results in progression to incurable castrate resistant prostate cancer (CRPC). Androgen signalling inhibitors (ASI), including Enzalutamide (ENZ) and Abiraterone (ABI), are effective treatments for …