Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Environmental chemicals"”.
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Anti-Ecdysteroidal Activity and Associated Toxicity of Environmental Chemicals in the Crustacean Daphnia magna.
… to characterize potential mechanisms by which environmental chemicals may disrupt ecdysteroid-regulated processes in crustaceans and the consequences of these perturbations. Several chemicals that are likely to elicit anti-ecdysteroidal activities through different mechanisms were selected and …
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Analytical Tools for Characterizing Developmental Toxicity of Environmental Chemicals Using High-throughput Screening in Zebrafish (Danio rerio).
North Carolina State University Theses Bioinformatics.
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DNA FRAGILE SITE BREAKAGE AS A MEASURE OF CHEMICAL EXPOSURE AND PREDICTOR OF THE SUSCEPTIBILITY TO FORM CHROMOSOMAL REARRANGEMENTS
… Fragile sites are sensitive to a variety of environmental chemicals and chemotherapeutic drugs and we have shown that treatment of human thyroid cells with laboratory fragile site-inducing chemicals can cause the formation of RET/PTC rearrangement. Here, we demonstrate that treatment with …
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Developmental Malformations in Zebrafish Caused by Exposure to Environmental Pollutants
… estimated that there are about 80,000 man-made chemicals released to the environment with little to no toxicity information. Exposure to these chemicals is identified as one of the risk factors for causing birth defects. We used zebrafish as a model to identify and predict environmental …
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Source identification of trichloroacetic acid with preparative capillary gas chromatography and accelerator mass spectrometry
A method for radiocarbon source identification of environmental chemicals present in soil at ppb levels using trichloroacetic acid (TCA) as an exemplary compound was developed in the present thesis. A powerful approach to differentiate between biogenic and anthropogenic sources of environmental …
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The Effect of Seven Carcinogens on Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Larvae of the Indian-Meal Moth
… well as provide a tool (or method) for assay of environmental chemicals for carcinogenic activity. </p>
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Bayesian and Frequentist Approaches for the Analysis of Multiple Endpoints Data Resulting from Exposure to Multiple Health Stressors.
… associated with exposure to stressors such as environmental chemicals. It consists of fitting a mathematical model to the exposure data and the BMD is the dose expected to result in a pre-specified response or benchmark response (BMR). Most available exposure data are from single chemical …
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The aryl hydrocarbon receptor signaling pathway and adverse reproductive outcomes
… because of factors such as exposure to environmental chemicals. For millions of women, the menopausal transition is accompanied by various debilitating symptoms including hot flashes and sleep disturbances. These symptoms may persist even years after they have started, leading to …
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Bisphenol A and Obesity
… However, there is increasing evidence that environmental chemicals, such as Bisphenol A (BPA), recently linked to altered adipose and glucose metabolism, may be aggravating the problem. Due to chronic human exposure, research is needed to confirm whether or not BPA is able to increase the …
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Design and synthesis of aryl hydrocarbon receptor fusion proteins for polyclonal antibodies production and cellular delivery
<p>Polycyclic aromatic hydrocarbons are environmental chemicals that are produced during incomplete combustion of coal, oil, gas, and garbage. Toxic effects of these compounds are mediated via the ligand activated Aryl Hydrocarbon Receptor (AHR) signaling pathway. To enable the study of the AHR …
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Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates
… testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative trend in male reproductive function. One important lifestyle factor is smoking. However, smoking during pregnancy appears to play a greater role …
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Compensatory renal hypertrophy, mitochondria and redox status
… renal proximal tubule cells to several drugs and environmental chemicals. Furthermore, our lab also showed that overexpression of mitochondrial GSH transporters, the dicarboxylate (DIC, Slc25a10) and 2-oxoglutarate (OGC, Slc25a11) carriers, in NRK-52E cells, which are derived from normal rat …
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… established between programmed axon death and environmental compounds associated with neuropathy, such as mitochondrial toxins, environmental pesticides, rodenticides, and chemotherapy drugs. Among these, pyridines have arisen as an important focus for programmed axon death. Pyridines are …
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Hydrogen peroxide-induced genotoxicity and transgenerational implications in sea urchins
… and dilute rapidly within days and considered environmentally friendly. However, modelling studies showed persistence of H<sub>2</sub>O<sub>2</sub> up to 1km from release sites. H<sub>2</sub>O<sub>2</sub> is a known genotoxicant and this thesis investigates degradation rates and genotoxicity in …
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An informatics approach to prioritizing risk assessment for chemicals and chemical combinations based on near-field exposure from consumer products
Over 80,000 chemicals are registered under the U.S. Toxic Substances Control Act of 1976, but only a few hundred have been screened for human toxicity. Not even those used in everyday consumer products, and known to have widespread exposure in the general population, have been screened. Toxicity …
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Effects of methoxychlor and its metabolites on mouse antral follicles
… response to endogenous hormones or exogenous chemicals. Currently, humans are exposed to numerous chemicals including organochlorine pesticides that are introduced into the environment on a daily basis. Some of these chemicals exert their toxicity by binding to estrogen receptors in …
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Influence of Insulin, Insulin-Like Growth Factor I and Sex Steroids On the Regulation of the Vitellogenin Receptor In Developing Oocytes of Largemouth Bass (Micropterus Salmoides)
… level and discern the ability of select environmental chemicals to interfere with pathways that control <italic>vtgr</italic>expression. </p> <p> During the normal reproductive cycle we discovered that <italic>vtgr</italic> was most highly expressed in ovarian tissues containing oocytes …
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Proteomic approaches to environmental stress in mussel Mytilus edulis due to emerging classes of anthropogenic pollutants
Anthropogenic pollutant chemicals pose a major threat to aquatic organisms. There is a need for more research on emerging categories of environmental chemicals such as nanomaterials, endocrine disruptors and pharmaceuticals. Proteomics offers options and advantages for early warning of alterations …
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Structure-Function Analysis of Insect Olfactory Receptors
… quality, and temporal features of volatile chemicals into spike trains. This dissertation focuses on understanding how the insect olfactory system functions at the periphery, shedding light on the molecular players involved and the interactions between environmental chemicals and OSNs. In …
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Der mikrobielle Umsatz von Ernterückständen in einem landwirtschaftlich genutzten Boden und dessen Beeinflussung durch ausgewählte Xenobiotika
… are preserved. Cultivation, fertilization, and environmental chemicals may affect the microbial communities and impair these processes. In the thesis presented, the effect of different active substance concentrations of the herbicide Benazolin and the PAH representative Benzo[a]pyrene on …
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