Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Environmental Toxicant"”.
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
<p>An important and unresolved question in the environmental health field is whether exposure to common environmental toxicants, such as dioxin and heavy metals like Pb, increase the risk of developing diabetes, especially in combination with other common metabolic stressors such as obesity. </p> …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… from the European Union in 2006 due to potential environmental and health risks, this common environmental toxicant is heavily used in the United States. ATR is the most common groundwater contaminant in the U.S. and millions of Americans are exposed to it daily. ATR has been associated with …
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Immune Suppression By The Herbicide Atrazine Involves Inhibition Of CD4+ T Cells And Expansion Of Foxp3+ Regulatory T cells
… from the European Union in 2006 due to potential environmental and health risks, this common environmental toxicant is heavily used in the United States. ATR is the most common groundwater contaminant in the U.S. and millions of Americans are exposed to it daily. ATR has been associated with …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… the first evidence for senescence induced by an environmental toxicant. As a component of cigarette smoke and as a hazardous air pollutant, DEB-induced senescence could contribute to the pathogenesis of lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… oxygen species from internal metabolism and environmental toxicant exposure, which have been linked to the initiation and progression of many neuronal diseases such as Alzheimer’s and Parkinson’s diseases. Exposure to reactive oxygen species are counterbalanced by antioxidant defense systems …
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DIFFERENTIATION-INDUCED CHANGES IN ANTIOXIDANT CAPACITY AND ANTIOXIDANT RESPONSE IN SH-SY5Y CELLS: ROLE OF NRF2
… oxygen species from internal metabolism and environmental toxicant exposure, which have been linked to the initiation and progression of many neuronal diseases such as Alzheimer’s and Parkinson’s diseases. Exposure to reactive oxygen species are counterbalanced by antioxidant defense systems …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… immune response to acrolein, a highly reactive environmental toxicant. Using a murine model with myeloid-specific overexpression of Arnt-a (homolog of human ARNT isoform 1), this study characterizes both the both the initiation (24-hours) and resolution (5-day) phases of acrolein-induced acute …
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Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
… pharmacological strategy to protect against environmental insults, such as exposure to solar ultraviolet (UV) radiation or the metalloid arsenic, that cause toxicity and cancer. In the first part of this dissertation, the achiote-derived apocarotenoid bixin was characterized as a novel NRF2 …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown physiological roles for the AhR in normal liver growth and development, insulin homeostasis, glucose homeostasis, and lipid metabolism. The liver is a …
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Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
… in chapter 2 demonstrates that exposure to the environmental toxicant bisphenol-A (BPA) causes increased methylation at the Hand2 promoter and reduced HAND2 expression. BPA also stimulated expression of fibroblast growth factors (FGF), stromal derived factors that drive uterine epithelial …
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Epigenetic effects of benzo(a)pyrene in Fundulus heteroclitus and Danio rerio
… gene expression and is vulnerable to early life environmental toxicant exposures. Our goal was to use two fish models, Fundulus heteroclitus and Danio rerio (zebrafish), to study the benzo(a)pyrene (BaP) effects on DNA methylation status and whether the alterations could contribute to …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
Arsenic is a globally prevalent environmental toxicant known to affect neurological and reproductive functions, yet critical gaps remain in our understanding of its sex-specific toxicity and heritable effects across generations. This thesis investigated the multigenerational cognitive and …
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Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
Manganese (Mn) is considered an environmental toxicant, known to cause a type of Parkinsonism called manganism. First observed in Mn ore crushers, the overexposure of Mn produces neurological signs and symptoms, predominantly motor impairment but can also elicit neuropsychiatric effects. The motor …
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Deciphering the roles of scaffold proteins (IQGAP1 and IQGAP2) and xenosensor (CAR) in liver biology
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01