Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Environmental Contaminant"”.
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X-ray absorption spectroscopy of actinide speciation in solid solutions
… to have a clear understanding of a waste form or environmental contaminant in order to effectively assess and treat the affected area. Current methodology utilizes the distribution coefficient (Kd), a rough measure of contaminant mobility in environmental systems, however neither the empirical nor …
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Towards a mechanistic understanding of contaminant attenuation and greenhouse gas emissions in open-water engineered wetlands
… the microbial interactions that govern contaminant biotransformations and greenhouse gas emissions within this benthic biomat community, leveraging a demonstration-scale open-water engineered wetland in Corona, California. Through an integration of field-scale genome-resolved …
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Effects of benzo[a]pyrene and CYP19a1b knockdown on zebrafish development
<p>Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact …
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… use and volatile nature, TCE is a common environmental contaminant. Trichloroethylene exposure has been implicated in the etiology of heart defects in human populations and animal models. Recent data suggest misregulation of Ca2+ homeostasis in a cardiomyocyte cell line after TCE exposure …
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Characterization of P-glycoprotein expression as a multixenobiotic resistance mechanism in fish
… fish species exposed in their natural habitat to environmental contaminants which may be P-gp substrates/inducers. We evaluated whether P-gp activity may be implicated in this multixenobiotic resistant phenotype. In winter flounder (Pleuronectes americanus) with contaminant-associated liver …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
Methylmercury (MeHg) is a pervasive environmental contaminant with potent neurotoxic, teratogenic and likely carcinogenic activity, for which the underlying molecular mechanisms remain largely unclear. Base excision repair (BER) is important in mitigating the pathogenic effects of oxidative stress, …
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Regulation of the MexAB-OprM Multidrug Efflux System of Pseudomonas aeruginosa: Involvement of Pentachlorophenol and Plant Chemicals
… (PCP), a phenolic compound that is a common environmental contaminant. Induction of mexAB-oprM and PA3720-armR by PCP was confirmed using RT-PCR, and MexAB-OprM was shown to be involved in PCP resistance. An electromobility shift assay (EMSA) showed that PCP interacts with NalC, interfering …
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The Effects of Chronic Cadmium Exposure on Breast Cancer Progression
<p>Cadmium is an environmental contaminant that enters the body usually through diet or cigarette smoke. Exposure to cadmium has been associated with the development of breast cancer. Recent studies have suggested that cadmium functions as an endocrine disruptor and mimics the actions of estrogen …
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Individual and Interactive Effects of Maternally- and Trophically-Derived Mercury on Early Amphibian Development
Mercury (Hg) is an important environmental contaminant due to its global distribution, tendency to bioaccumulate, and toxicity to wildlife. However, Hg has received little attention in amphibians compared to other vertebrates, despite the fact that amphibian population declines have been documented …
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The Interactive Effects of Multiple Stressors on Lithobates catesbeianus and Anaxyrus americanus
… amphibians serve as indicator species of overall environmental health. Major causes for amphibian declines are discussed in Chapter 1 and include: habitat modification and destruction, commercial over-exploitation, introduced species, environmental contaminants, global climate change, and …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
In utero exposure to benzene, a known environmental contaminant, is associated with increased risk of childhood leukemia. We have previously shown that in utero benzene exposure can alter the redox sensitive transcription factor NF-κB, which is up-regulated in leukemia. We hypothesize that this is …
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Bioremediation of Trichloroethylene: Analysis of the Plant Gene Response to TCE and Characterization of a Novel TCE-Degrading Endophyte
Trichloroethylene is a common environmental contaminant. High levels of TCE have the potential to cause liver damage and malfunctions in the central nervous system, and it is considered a likely human carcinogen. More than 54% of Superfund sites in the United States are contaminated with TCE. This …
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Tissue-Specific Mediation of Estrogen-Induced Epithelial Events by the Estrogen Receptor in Female Reproductive Tract Organs
… were exposed to the suspected antiestrogenic environmental contaminant and aryl hydrocarbon receptor (AhR) ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), normal E2-induced uterine epithelial function was inhibited. However, uterine epithelial function in mice that lack AhR (AhRKO) was not …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… studies could explain how both physiological and environmental contaminant estrogens influence DAT-dependent diseases.
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Application of manganese oxide minerals to treat acidic waters contaminated with vanadium
Vanadium (V) is both toxic environmental contaminant and a strategically valuable metal, increasingly being released from metallurgical and energy industries. Its high mobility and toxicity under acidic conditions challenge conventional remediation technologies, while its growing demand creates …
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Anti-Ecdysteroidal Activity and Associated Toxicity of Environmental Chemicals in the Crustacean Daphnia magna.
… to characterize potential mechanisms by which environmental chemicals may disrupt ecdysteroid-regulated processes in crustaceans and the consequences of these perturbations. Several chemicals that are likely to elicit anti-ecdysteroidal activities through different mechanisms were selected and …
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Toxicity of TCDD in the mouse antral follicle
The persistent environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent ovarian toxicant. These studies were designed to characterize the actions of TCDD on steroidogenesis, growth, and atresia of intact mouse antral follicles in vitro. Interestingly, TCDD has been shown to …
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… additional unidentified genetic contributors and environmental factors. A major focus of this thesis is CHARGE syndrome (CS), a multisystem disorder clinically overlapping with IGD and primarily caused by heterozygous loss-of-function variants in the CHD7 gene, encoding a chromatin remodeler …
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I. In vitro selection of aptamers for perchlorate and melamine II. Towards crystallization of DNAzymes III. A highly selective lead sensor based on a classic lead DNAzyme
… In addition, perchlorate is also a ubiquitous environmental contaminant. Current detection methods for perchlorate are cumbersome and not suitable for routine environmental monitoring. Isolating an aptamer for perchlorate can facilitate the development of aptamer based biosensor for more …
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Efeitos da ingestão subcrônica de arsênio sobre os testículos de camundongos adultos
A toxicidade de um agente químico depende de sua propensão inerente de produzir danos ao sistema biológico com o qual interage. O arsênio (As), um conhecido poluente ambiental, merece destaque como elemento potencialmente tóxico para a função reprodutiva masculina. A exposição ao As pode afetar o …