Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Envelope Glycoprotein"”.
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Biogenesis, Assembly and Intracellular Trafficking of Junin Arenavirus Envelope Glycoprotein Complex
An unusual feature in the arenavirus envelope glycoprotein complex (GP-C) is the presence of a myristoylated stable signal peptide (SSP) in addition to the receptor binding subunit G1 and the transmembrane fusion subunit G2. Genetic studies were employed to understand the structure-function of the …
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Molecular Analysis of Hepatitis C Virus Envelope Glycoprotein E2 Binding and Entry
The envelope of the hepatitis C virus (HCV) mediates entry into cells by binding directly to the cluster of differentiation 81 receptor (CD81) and to the scavenger receptor class B type 1 (SR-B1). The critical incorporation of claudin-1 receptor (CLDN-1) and occludin receptor (OCLN) (indirect …
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The effect of envelope glycoprotein gI on the replication of pseudorabies virus in porcine alveolar macrophages
… are genetically engineered for deletion of the envelope glycoprotein gI because of the association of gI with virulence.
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In vitro and In vivo Characterization of the Infection Efficiency of a Modified Retrovirus Envelope Glycoprotein for Targeting Gene Transduction
<p>Attributes of both the viral glycoprotein and its cellular receptor play key roles in determining the outcome of infection. This body of work endeavors to illustrate how these two components influence the efficiency of virus infection in in vitro and in vivo systems with an emphasis on …
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Single Molecule Imaging of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein Dynamics Identifies Viral Elements Contributing to Infectious Particle Assembly
… a host. Though it is known that the viral spike glycoprotein, Envelope (Env), responsible for viral entry into a host immune cell, is essential in propagation of infection, the mechanism of its incorporation into newly assembling infectious particles remains ill understood. We observe, in real …
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Generation and characterization of HIV-1 subtype C candidate vaccines that will induce high titre antibody responses to HIV-1 envelope glycoprotein
… Africa. Specifically, this involved use of the envelope glycoprotein sequence of the CAP256 superinfecting virus (CAP256_SU) from the CAPRISA 002 cohort, and a mosaic Gag sequence which resulted in robust autologous Tier 2 neutralisation of CAP256_SU pseudovirions. The envelope glycoprotein …
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HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
The HIV-1 envelope glycoproteins gp120 and gp41 mediate binding and fusion of the virus to target cells. The envelope glycoproteins are exposed on the surface of the virus as trimeric spikes and are the major targets for neutralizing antibodies. The design of envelope glycoprotein-based subunit …
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Mechanisms of CCR5 Agonist/Antagonist Inhibition of HIV-1 Entry and In Vitro Selection of Virus Resistant to Maraviroc
… inhibitors target interactions of the viral envelope glycoprotein with host cell receptors as well as fusion of the viral and host cell membranes. Extensive development of inhibitors that target CCR5, a cellular coreceptor required for viral entry, has resulted in molecules with potent …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… frequently focused on the possible role of the envelope glycoprotein, gpl20, as a mediator of excitotoxicity. Many animal retroviruses of veterinary importance produce neurologic and immunologic syndromes similar to those manifest by HIV-1. The feline retroviruses, feline immunodeficiency virus …
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Modulating the Antigenicity and Immunogenicity of HIV-1 Envelope by a Conserved N-Linked Glycan
… 197 (N7) on the surface antigen gp120 of HIV-1 envelope glycoprotein (Env) increases neutralization sensitivity of the mutant virus to CD4 binding site (CD4bs)-directed antibodies and enhanced the ability of Env to generate cross-reactive neutralizing responses as compared to its WT counterpart. …
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RNA transmission and expression from inert HIV candidate vaccine virus-like-particles
… Non-pseudotyped VLPs that do not present any HIV envelope glycoproteins are regarded as inert particles as they contain no replicative nucleic acid and are presumed to be unable to deliver encapsidated RNA for expression in inoculated individuals. Live virus cellular entry studies have shown that …
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A Biophysical Investigation of HIV-1 Envelope Cytoplasmic-Tail Mediated Retention in the Gag Lattice
… successful incorporation of the trimeric viral envelope glycoprotein, Envelope (Env), into Gag lattice assembly sites on the host-cell plasma membrane during virus biogenesis. The mechanistic nature of interaction between Gag, the structural protein, and Env, the viral spike, are dependent on …
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Inhibiting HIV-1 entry : utilizing a transient intermediate of viral membrane fusion as a target for drug discovery
In order to reproduce, enveloped viruses must deposit their genomes into host cells. The first step of this process is the fusion of viral and cellular membranes, which allows the release of the viral contents into the cell. An envelope glycoprotein on the surface of the virus is responsible for …
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A Novel Gene Therapy Approach Based on Secreted Antiviral Proteins for the Control of HIV Replication
… target cells requires the interaction of the HIV envelope glycoprotein (Env) with a primary receptor (CD4) and a co-receptor (most commonly CCR5 or CXCR4). Protein-based HIV entry inhibitors are highly effective in protecting cells from infection. However, their clinical application is limited …
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Evaluation of a Tetravalent DNA Vaccine against Dengue: Integrating Biochemical Studies on Dengue Virus Envelope Protein to a Domain-Based Antigen Design.
… using alternative approaches. Given that the envelope glycoprotein (E) is the main target of neutralizing antibodies, it has been used as the antigen of choice for vaccine development efforts. Here we present a detailed analysis of factors involved in the expression, secretion and folding of …
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Solid-state NMR investigation of viral fusion glycoprotein 41 (gp41)
… cellular processes and viral entry. The HIV envelope glycoprotein mediates viral entry into target cells by fusing the viral envelope with the cell membrane. This process requires large-scale and multi-step conformational changes of the viral fusion protein gp41. Our current understanding of …
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