Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Entinostat"”.
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Effect of Entinostat On Nk Cell-Mediated Cytotoxicity Against Os Cells and Os Lung Metastsis
… to investigate the effect of the HDAC inhibitor entinostat on the efficacy of NK cell therapy for OS lung metastasis. The Lung is the most common site of OS metastatic spread in OS and pulmonary metastasis is the main cause of mortality. We have previously demonstrated that NK cell therapy has …
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Development of orthogonal nanotherapeutics for colorectal cancer treatment
… that FLIPL depletion by the HDAC inhibitor Entinostat results in synergistic induction of cell death following combined RG388 and Entinostat treatment in p53 wild-type colorectal cancer model.<br/><br/>The combination of therapies that work by different modes of action is a standard regimen …
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HDAC inhibition results in suppression of FOXM1 and genes associated with poor prognosis prostate cancer through p53 dependent and independent mechanisms
… demonstrates that the Class I HDAC inhibitor, Entinostat, augments the effects of both the p53 activating MDM2 inhibitor, Nutlin-3A and radiotherapy, resulting in a synergistic induction of cell death dependent on WT p53. Further exploration into the mechanism of cell death demonstrated …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
… of two different HDACi (vorinostat or entinostat) with adaphostin synergistically induced apoptosis in ALL. This synergistic effect was blocked when cells were pre-treated with the caspase-9 inhibitor, LEHD. In addition, we showed that loss of the mitochondrial membrane potential is the …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… Nutlin-3A, and the Class I specific HDACi, Entinostat, when compared to Nutlin-3A treatment alone. Indeed, the addition of Entinostat was instead found to decrease the expression of p53 induced anti-apoptotic proteins which most notably included the only known pseudo-caspase and cell death …
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Role of epigenetics in hematopoietic stem cell development
… to these results, the two eraser molecules, entinostat (class I histone deacetylase, or HDAC, inhibitor) and vorinostat (general HDAC inhibitor), were found to decrease HSC formation in zebrafish. The overall findings of this study provide insight into specific epigenetic regulators in HSC …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… being developed for clinical use. One example is entinostat which has been shown to selectively inhibit<br/>HDACs 1,2 and 3. We found that treatment with entinostat also downregulated FLIP and combination treatments with cisplatin or TRAIL were in most cases equally or more effective than …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… mediator of this resistance mechanism. Moreover, Entinostat, a clinically relevant Class I HDAC inhibitor, was found to downregulate FLIP expression and sensitise CRC cell line models to ASTX660. Through the use of procaspase-8 and procaspase-10 CRISPR-Cas9 knockout cell lines, the enhanced cell …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… expressed in CaP and the Class 1 specific HDACi Entinostat (ENT) has been awarded FDA designation as a breakthrough therapy for aromatase inhibitor (AI)-resistant breast cancer in combination with hormone therapy demonstrating its potential to be used for treatment of solid tumours including CaP. …