Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Enterolactone"”.
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… work is to evaluate the effects of the lignan enterolactone (ENL) and LOBs on intestinal epithelium function and how it might influence associated pathologies like inflammatory bowel disease (IBD) and hypercholesterolemia. We first assessed LOBs and ENL effects on barrier integrity (a …
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Plant foods, plasma enterolactone and breast cancer - with a focus on estrogen receptor status and genetic variation
… example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen receptors (ERs) and, therefore, inhibit the effect of estrogens. The aim of this doctoral project was to prospectively …
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The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
The mammalian lignan, enterolactone (EL), is a gut microbe metabolite of plant lignan secoisolariciresinol diglucoside (SDG), which is most abundant in flaxseed. Numerous epidemiological, experimental and clinical studies suggest the protective effects of EL against various chronic diseases such as …
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EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… combination of the bioactive mammalian lignan, enterolactone (ENL), and selected tyrosine kinase inhibitors (TKIs) and to explore whether these effects involve peroxisome proliferator-activated receptor gamma (PPARγ), oxidative stress, and/or endoplasmic reticulum (ER) stress, known pathways of …
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Protective role of lignan-converting bacteria on chemically-induced breast cancer in gnotobiotic rats
Enterolignans (enterodiol and enterolactone) exhibit structural similarity to estradiol and have therefore been hypothesized to modulate hormone related cancers such as breast cancer. The bioactivation of the plant lignan secoisolariciresinol diglucoside (SDG) requires the transformation by …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… putative mechanisms of action for the lignans, enterolactone and isoalantolactone, and to identify other potential drug candidates for targeting PC cytometabolic and cytoskeletal stress vulnerabilities, in several different heterogeneous sub-types of PC by the use a myraid of in vitro cell and …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… of action, the effect of the mammalian lignan, enterolactone (ENL), and its metabolite, enterolactone glucuronide (ENL-Gluc), on hepatic trafficking of the fluorescent cholesterol probe NBD-cholesterol, was investigated using fluorescence microscopy in the HepaRG cell line as an in vitro liver …
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THE EFFECT OF FLAXSEED AND ITS LIGNAN COMPONENT ON ESTROGEN SIGNALING AND METABOLISM IN NORMAL AND CANCEROUS HEN OVARIES
… have not been fully explored. SDG metabolites, enterolactone (ED) and enterodiol (EL) can decrease ER signaling by competing for binding sites with E2, potentially decreasing expression of E2 target genes involved in proliferation and survival. Our goal was to analyze the effect of flaxseed diet …