Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Enteroendocrine"”.
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Sensory Transduction in Enteroendocrine Cells
… a central function of the gut epithelium where enteroendocrine cells act as sensor cells to secrete hormones in response to the luminal contents. This thesis focuses on voltage gated ion channels and the transient receptor potential (TRP) superfamily in I cells and enterochromaffin cells using …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
Enteroendocrine cells (EECs) are chemosensitive cells of the gastrointestinal epithelium that exert a wide range of physiological effects via production and secretion of hormones in response to ingested nutrients, bacterial metabolites and systemic signals. Glucagon-like peptide-1 (GLP-1) is one …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… proglucagon gene. To examine this, we treated enteroendocrine L cells with butyrate and found increased proglucagon mRNA abundance. However, the mechanism by which butyrate affects proglucagon was less understood. Therefore, we isolated the human proglucagon gene promoter and treated with …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… proglucagon gene. To examine this, we treated enteroendocrine L cells with butyrate and found increased proglucagon mRNA abundance. However, the mechanism by which butyrate affects proglucagon was less understood. Therefore, we isolated the human proglucagon gene promoter and treated with …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
Enteroendocrine cells (EECs) of the gastrointestinal (GI) tract and islets of Langerhans (islets) of the pancreas are endocrine cells capable of sensing nutrient intake or the nutrient content of the blood and responding by secreting peptide hormones to control various physiological functions. This …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… body thanks to the presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such as nutrient digestion and absorption, …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… Many gut hormone peptides are secreted by enteroendocrine cells (EECs) and some, known as incretins, are released after a meal to control blood glucose and stimulate neuronal satiety. These are being studied as novel targets for treatment of metabolic diseases such as obesity. Traditionally …
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Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
The mechanisms and neurochemical pathways through which the orexigenic peptide hormone ghrelin act to regulate homeostatic feeding is fairly well documented. However, less understood are the mechanisms and brain regions that mediate ghrelin's effects on mood and complex eating behaviors. At the …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… used to assess the development of the ENS and enteroendocrine cells (EECs), respectively. At PD1, the ENS of AGA animals was almost fully developed compared with PD14 and PD28. For SGA piglets, a delayed development of nerve endings was observed on PD1 associated with a less developed synaptic …
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Pre-, pro-, and synbiotic modulation of the intestinal microbiota stimulates enteroendocrine mediated intestinal adaptation in piglets with short-bowel syndrome
… and antibiotic use. SBS is associated with an enteroendocrine cascade beginning with intestinal secretion of glucagon-like peptide-2 (GLP-2), an intestinotrophic hormone, stimulating innate intestinal adaptation. Treatments such as prebiotics and probiotics that increase luminal production of …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… show that Gpr41 is expressed in the intestinal enteroendocrine cells. The localization of Gpr41 to enteroendocrine cells suggests that SCFAs signaling through Gpr41 induces the enteroendocrine cells to release a soluble mediator. In this study we sought to study the effects of SCFAs signaling on …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… bariatric procedures correlates with altered enteroendocrine profiles. G-protein coupled receptors (GPCR)s are considered attractive targets to modulate incretin secretion. The aim of this dissertation was to investigate the contributions of GPCRs to incretin secretion. Receptors of interest …
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Dynamic Responses at the Barrier Epithelium
… 4 characterizes a novel response of the enteroendocrine system to pathogenic challenge. Enteroendocrine cells are professional secretory cells with the capacity to signal through various peptide hormones. These hormones regulate important aspects of local and organismal physiology. We …
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A Novel Genetic Platform to Study Intestinal Tumorigenesis in Drosophila
… our research has revealed that transformed enteroendocrine cells, which are a specialized lineage of intestinal hormone-secreting cells, play a crucial role in supporting tumor growth via the regulation of the proliferation of intestinal stem cells through multiple mechanisms that depend on …
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Generation and use of new tools for the characterisation of gut hormone receptors
Enteroendocrine hormones released from the intestine following food intake have several roles in the control of metabolism, some of which are exploited therapeutically for the treatment of type 2 diabetes. Within this thesis, focus has been on the receptors of the gut hormones glucagon-like …
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Morfologia comparada do estômago e da junção gastroduodenal de morcegos da família Phyllostomidae (Mammalia, Chiroptera)
… in the stomach wall. The distribution of the enteroendocrine cells is also described. Cladistic evaluations of the information content of phyllostomid digestive system indicate quite promising results.
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The metabolic sequelae of oesophago-gastric resection
… based peptidomics of human and murine enteroendocrine cells in the pre- and post-operative populations revealed no significant change in the underlying cellular pathways for nutrient sensing and gut hormone secretion, indicating that the altered hormone secretion is primarily driven by …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… epithelial cells, specifically tuft cells and enteroendocrine cells (EECs), in colonic inflammation, revealing novel cellular and molecular dynamics. The initial study utilized IEC-specific Hnrnp I knockout mice to demonstrate significant upregulation of pro-inflammatory cytokines such as Il1β, …
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