Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Enterobactin"”.
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… and biosynthesis are discussed with a focus on enterobactin and salmochelins, which are the two siderophores studied in this thesis. The notion of conjugating functional molecules to siderophores has been actively studied for decades. The syntheses and applications of siderophore conjugates are …
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Synthesis of novel pendant arm macrocyclic ligands as potential models for enterobactin
A series of pendant arm tris-catecholate macrocyclic ligands were synthesized. The first, based on 1,4,7- triaminopropyl-1, 4, 7-triazacyclononane, was prepared via condensation with 2,3-dimethoxybenzoyl chloride. The deprotection of the catechol moieties was achieved with boron tribromide in 80% …
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Characterization of a Catechol-Type Siderophore and the Detection of a Possible Outer Membrane Receptor Protein from <em>Rhizobium leguminosarum</em> strain IARI 312.
… characterized, and is consistent with that of enterobactin.</p>
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… from the environment. Our approaches focus on enterobactin (Ent) and its glycosylated derivatives (GIcEnt), which are virulence factors of certain enteric pathogens, such as Salmonella spp. The first approach relies on the use of GlcEnt-[beta]-lactam conjugates to target these pathogens. In …
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Analysis of the diverse antibacterial strategies used by <i>Serratia marcescens</i> Db10
… of the surfactant, serrawettin W2, and an enterobactin-like siderophore. These PswP dependent metabolites are all shown to possess antimicrobial activity against the Gram-positive bacterium, <i>Staphylococcus aureus</i>.<br/><br/>The Type VI Secretion System (T6SS) is the most recently …
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Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative Bacteria
… the application of a SAC strategy based on enterobactin (Ent), a native triscatecholate siderophore, to repurpose platinum (Pt) anticancer agents as targeted antibiotics against Gram-negative bacteria, involving four Ent-based conjugates incorporating Pt(V) prodrugs (Ent–Pt(IV)). Chapter 1 …
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CHARACTERIZING THE ROLE OF PUTATIVE VIRULENCE GENES ASSOCIATED WITH INFECTION, COLONIZATION AND PERSISTENCE OF SALMONELLA ENTERITIDIS IN CHICKEN USING A BIOLUMINESCENT REPORTER
… iron uptake systems namely siderophore (enterobactin and salmochelin) mediated ferric iron uptake and FeoABC-mediated ferrous iron uptake. Our approach was to use mutant strains devoid of each of the uptake systems in a co-infection chicken model together with the wild-type strain. One …