Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Enteric pathogen"”.
-
Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
… Treatment and vaccination options for both pathogens have significant limitations. C. difficile infections are treated with antibiotics, which is paradoxical as C. difficile itself is associated with antibiotic usage. In the United States, two live oral attenuated vaccines (Rotarix and …
-
Human enteroids as a model for infectious disease
… (GI) tract is a major site of host-pathogen interactions. As such, many human pathogens have evolved to either use the GI tract as a portal of entry to gain access to distal sites in the body or cause acute disease within the GI tract. For many years we lacked a suitable cell culture …
-
The Effects of Water Storage and Meteorological Conditions on Enteric Infections from a Matched-Control Trial in Beira, Mozambique
… has the potential to reduce the burden of enteric diseases, including diarrhea, in rapidly growing urban centers. However, water intermittency and water storage practices, as well as impacts of meteorological conditions, may interfere with the progress made by drinking water interventions. …
-
Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… rodentium, a well characterized rodent-specific enteric pathogen as a source of extrahepatic inflammatory stress; host liver responses, metabolic dysregulation, and susceptibility to injury in C57BL/6 mice were investigated. For the first time, we show altered liver pathology during the early …
-
Control of Salmonella Virulence by Microbiota-Derived and Dietary Fatty Acids
… host immunity to defend against invading pathogens, how microbiota directly antagonizes pathogen virulence is less studied. In particular, gut microbiota produces large amounts and varieties of small molecules that may impact both host immunity and pathogen virulence. In this thesis, I …
-
Elucidating fecal contamination exposure in low-income countries, the contribution from child feces disposal practices and soil ingestion, and links to child health
Enteric pathogens transmitted via fecal-oral pathways cause enteric infections that have substantial health and human capital consequences, making it critical to reduce child exposure to fecal contamination. Current water, sanitation, and hygiene programs in low-income countries often focus on …
-
Analyzing the Role of Mucin O-Glycans in Regulating Microbial Virulence
… microbial physiology in the opportunistic fungal pathogen, Candida albicans, and the gram-negative bacterial pathogen, Vibrio cholerae. First, I purify and characterize libraries of mucin-attached glycans and establish their role in influencing C. albicans pathogenicity, group behavior, and …
-
Development of a novel carbohydrate-based method for the detection of norovirus from ready-to-eat foods
Norovirus is an enteric pathogen transmitted via the fecal-oral route. It is a leading cause of outbreaks and sporadic cases of gastroenteritis worldwide. Outbreaks of norovirus are often linked to contaminated food or water. Ready-to-eat foods are particularly prone to contamination, since they …
-
Bacteriophage PRD1 as a potential surrogate for adenovirus in drinking water disinfection with free chlorine, low pressure ultraviolet light, and sunlight
Waterborne pathogens are increasingly a worldwide concern in drinking water because of their ability to cause high levels of morbidity and mortality. Especially in developing regions, a lack of access to safe drinking water, adequate sanitation, and resources to implement water treatment processes …
-
Giardia trophozoite-secreted proteins and their effects on intestinal epithelia
… worldwide. It is a flagellated cyst-forming enteric pathogen that inhabits the lumen of the small intestine. Two genetically distinct lineages (assemblages A and B) are of public health relevance and are often associated with water-borne outbreaks. Yet, the mechanism of pathogenesis and …
-
The Role of Host Hormones and Metabolites in the Regulation of Virulence in Enterohemorrhagic Escherichia coli (EHEC)
Gastrointestinal bacteria, including the enteric pathogen enterohemorrhagic Escherichia coli O157:H7 (EHEC) that causes hemorrhagic colitis, sense diverse environmental signals, and use them as cues for differential gene regulation and niche adaptation. This allows for a temporal and energy …
-
Characterization of QSEA and QSED in the Quorum Sensing Cascade of Enterohemorrhagic Escherichia Coli
Enterohemorrhagic E. coli O157:H7 (EHEC) is an enteric pathogen that has been implicated in many outbreaks of bloody diarrhea worldwide. EHEC senses its environment through quorum sensing, a mechanism by which bacteria use chemical signals, termed autoinducers, to regulate key genes. In the …
-
THE ROLE OF HYALURONAN IN INNATE INTESTINAL DEFENSE
… enhanced resistance to infection by the enteric pathogen <i>Salmonella enterica</i>. Together, these observations suggest that maternally provided HA mediates one of the multiple protective antimicrobial defense mechanisms delivered through milk to the newborn.
-
Investigation into the transcriptional regulation and role in virulence of the Type VI Secretion System of <em>Serratia marcescens</em> Db10
… Serratia marcescens (Sma) is an opportunistic enteric pathogen which is responsible for causing severe hospital acquired infections in vulnerable patients. The insect pathogen Sma Db10 possesses a functional T6SS which targets antibacterial effector molecules to kill competitor bacteria. The …
-
Investigating novel treatment approaches to combat Clostridioides difficile
… in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United States Center for Disease Control and Prevention (CDC), capitalizes on disrupted intestinal microbiome to establish infection with disease symptoms ranging from mild diarrhea to …
-
Deciphering the relationship among nutrition, host and microbe
… dietary fatty acids were applied directly to the enteric pathogen, Yersinia enterocolitica. Arachidonic acid is an omega-6 fatty acid that is found in high concentrations in the Western diet and has been associated with inflammation. Therefore, this study analyzed how arachidonic acid altered the …
-
Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… to colonize this niche. An invading intestinal pathogen, to effectively colonize the gut, must sense and respond to the molecular signatures in the gut, which leads to effective colonization and infection. Diet is the principal source of energy by the intake of three main nutrients: …
-
Multi-omics investigation of interactions between persistent bacteria and Salmonella in the inflamed gut
Salmonella is a globally relevant enteric pathogen responsible for numerous outbreaks and debilitating illness yearly. Expansive tropism allows Salmonella to find bastion in zoonotic reservoirs including prominent food animals. Continued prophylactic antibiotic use in livestock and therapeutic …
-
Agent-based and contact network modeling applications for Escherichia coli transmission in commercial feedlot settings
… coli (STEC) are recognized as a major food-borne pathogens with outbreaks, human infections, and occasional deaths associated with the consumption of contaminated foods. Cattle are recognized as a primary reservoir for STEC, though the transmission dynamics of STEC in feedlot cattle are not fully …