Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 33 for “"Enteric nervous system"”.
-
Neuronal plasticity in the enteric nervous system motor pathways
… underlying neurotransmission within the enteric nervous system are not yet known. Acetylcholine acting on nicotinic receptors mediates the majority of fast synaptic transmission between enteric neurons, however, recent studies suggest that the peristaltic motor pattern can occur during …
-
Genetic Control Of Enteric Nervous System Development And Subtype Specification
… and sometimes, early death. In HSCR, the enteric nervous system (ENS) does not develop completely, resulting in a region of bowel lacking neurons. HSCR can be treated by surgically removing aganglionic bowel, but many children with HSCR have poor motility even after surgery, especially …
-
A Molecular Basis for Macrophage Control of Enteric Nervous System Function
… between intestinal macrophages and the enteric nervous system regulate gastrointestinal motility, yet we have an incomplete understanding of the molecular mediators of this crosstalk. Here we identify complement component 1q (C1q) as a macrophage product that regulates gut motility. …
-
Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest …
-
Characterization of the Expression and Pathogenicity of Alpha-Synuclein in the Enteric Nervous System
… not only in brain tissues, but also in the enteric nervous system (ENS). Here, we aimed to reevaluate the localization pattern of α-Syn in the ENS of PD patients and control subjects. Formalin-fixed and paraffin-embedded (FFPE) full-thickness colon resections were used to characterize α-Syn …
-
Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… earlier susceptibility to HD. While HD central nervous system symptoms are well-documented, the ubiquitous expression of mutant huntingtin results in a range of peripheral symptoms, including gastrointestinal (GI) disturbances. These symptoms, which appear as early as the prodromal phase, …
-
Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System
The vertebrate enteric nervous system (ENS) consists of a series of interconnected ganglia within the gastrointestinal (GI) tract, formed during development following the migration of enteric neural crest cells (ENCCs) into the primitive gut tube. Much work has been done to unravel the complex …
-
Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… birth weight and diet on the development of the enteric nervous system (ENS) and entero-endocrine system (EES) during the first month of life, via multivariate analyses. Newborn SGA or AGA (average for gestational age) piglets were randomized into two diet groups: sow reared (SR, 24h/day with the …
-
Intrinsic Neural Control of Propulsion, Storage and Slow Transit in the Large Intestine.
… in this dissertation have examined how the enteric nervous system regulates specific aspects of gastrointestinal motility. We have identified, despite over 100 years of gastrointestinal research, a new intrinsic neural reflex that appears to underlie slow transit and accommodation in the …
-
Neuroglial differentiation and neo-innervation in extracellular matrix-based tissue engineered innervated smooth muscle sheets
Excitatory and inhibitory motor neurons of the myenteric plexus in the enteric nervous system regulate and coordinate smooth muscle motility. Enteric neurons and glia of the myenteric plexus are organized into ganglia, that are surrounded by an extracellular matrix composed primarily of collagen …
-
Human intestinal cells across space and time
… as well as key cell types (e.g. epithelium, enteric neurons, stromal and immune cells) required for the proper intestinal function, will be summarized. As an intestinal surface area, innervation and immunity are established during in utero development, this chapter will also outline the …
-
BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE
… tract. The GI tract is a highly complex organ system with multiple cells layers organized in a structured architecture. Peristalsis is dictated by 2 smooth muscle layers; the outer longitudinal and inner circular muscle layer along with their innervation provided by the enteric nervous system. …
-
Variation resolutions for CMOS sensing networks
… signal, which complicates both the sensor system design and the associated signal analysis. We will illustrate a spike-sorting method to reliably classify the enteric neural signals which have unique waveform features but large variation in magnitude, timing and duration. The proposed …
-
RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… megacolon and/or the failure to pass meconium. Enteric neurons are derived from neural crest cells (NCC); hence HSCR is associated with incomplete NCC development or colonization of the GI tract. We investigated our hypothesis that RDH10 is necessary for proper NCC contribution to the enteric …
-
Sistema nervoso enterico e scrapie sperimentale in ovini di razza sarda con diversa suscettibilità genetica nei confronti della malattia
Sebbene il sistema nervoso enterico (“enteric nervous system”, ENS) svolga un ruolo cruciale nella patogenesi della Scrapie ovina, non esistono tuttavia in letteratura dati sulle popolazioni cellulari progressivamente coinvolte nel corso dell’infezione, né sugli eventuali danni morfo-funzionali da …
-
Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may occur in intestinal inflammation, due to the …
-
Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… assay was then used in combination with enteric nervous system (ENS)-deficient zebrafish, a model for Hirschsprung’s disease (HSCR), to study the effects of the ENS on the colonization and virulence gene expression of enterohemorrhagic <em>Escherichia coli</em> (EHEC). My findings suggest …
-
Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… reperfusion affects the large intestine and the enteric nervous system (ENS). To do so an experimental ischemia/reperfusion (I/R) model was set up using rat large intestine. In order to study how the ENS reacts to various mediators of stress, primary cultures of myenteric neurons from rat small …
-
Development Of Bioelectronic Sensors For Real Time Monitoring Of Gastrointestinal Health
… this thesis focuses on the gastrointestinal (GI) system, which plays an essential role in maintaining homeostasis within the body, by facilitating digestion, nutrient absorption, and waste excretion. Beyond its fundamental functions, the GI system is intricately connected to various aspects of …
-
Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… functions are coordinated by neurons within the enteric nervous system (ENS). While intestinal inflammation initially causes a profound loss of enteric neurons, the ENS demonstrates remarkable changes in neuronal structure and function to retain control of gastrointestinal functions. Expression …
Page 1 of 2