Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Enteric Pathogens"”.
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… molecules in dictating the infectivity of an enteric pathogen remains unknown. Because the concentrations of these small molecules naturally present in the body are in the range of the drug concentrations that are used to treat certain diseases, it is possible to repurpose the information …
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Transdisciplinary Strategies for the Characterization of Mucosal Immune Responses to Enteric Pathogens
… disease outcome and pathogenesis. By using model enteric microorganisms Helicobacter pylori and Clostridium difficile, this dissertation presents a systematic effort to generate novel mechanistic hypothesis based on computational predictions and experimentally elucidate the mechanisms of action …
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Development and Evaluation of a Multiplex Suspension Array Protocol for the Detection of Enteric Pathogens from Clinical Specimens
… Timely detection and identification of the pathogens causing foodborne outbreaks is vital for the implementation of outbreak control strategies, allowing public health officials to prevent additional illnesses and maintain confidence in the food supply. Public health laboratories employ a …
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Detection and Identification of Gastrointestinal Pathogens in Clinical Samples: Comparison Between two Laboratory Developed Multiplex Real-Time PCR Platforms
… gastroenteritis is caused by a wide range of enteric bacteria pathogens including <em>Salmonella, Shigella, Campylobacter jejuni, </em>and <em> E. coli </em>0157. Conventional methods used in the detection of such pathogens including, culture, microscopy, biochemical identification, and …
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Elucidating fecal contamination exposure in low-income countries, the contribution from child feces disposal practices and soil ingestion, and links to child health
Enteric pathogens transmitted via fecal-oral pathways cause enteric infections that have substantial health and human capital consequences, making it critical to reduce child exposure to fecal contamination. Current water, sanitation, and hygiene programs in low-income countries often focus on …
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Microbial Ecology and Horticultural Sustainability of Organically and Conventionally Managed Apples
… pressures contribute to an increased presence of enteric pathogens in phyllosphere microflora. The horticultural and economic sustainability of the organic crop was also compared to the conventional crop with regard to fruit yield and input costs. Methods: Microbial populations from phyllosphere …
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Molecular Characterization of Spinach (Spinacia Oleracea) Microbial Community Structure and its Interaction With Escherichia coli O157:H7 in Modified Atmosphere Conditions
… bacteria may play a role in the establishment of enteric pathogens on leaf surfaces. The objective of this study was to characterize the bacterial communities of fresh and packaged spinach leaves and to explore interactions with E. coli O157:H7. We assessed the bacterial diversity present on the …
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Investigating Private Drinking Water Quality and Biomarkers of Associated Health Outcomes in Southwest Virginia
… analyzed for fecal indicator bacteria, specific enteric pathogens, metals, nutrients, and other inorganic ions. Though private sources are not subject to EPA regulations, water quality results were compared to US EPA maximum contaminant levels (MCLs), secondary maximum contaminant levels (SMCLs), …
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Predicting Colonization of Microbes in the Human Gut
… critical for protecting humans from infectious enteric pathogens. However, it is detrimental to the deliberate engraftment of probiotics which are live microbes beneficial to the host. The mechanisms behind these barriers have been studied extensively, but the microbiome is a network of many …
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Application of Quantitative Microbial Risk Assessment to Domestic Hygiene
Enteric pathogens have long been a global health burden. The advancement of domestic hygiene has advanced societies for millennia as the ability to manage waste greatly reduces the public health risk of pathogen spread. The domestic restroom, more specifically the modern-day toilet is both a source …
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Quantification of multiple waterborne pathogens in drinking water, drainage channels, and surface waters in Kampala, Uganda over seven months of seasonal variation
… was used to assess the presence of human enteric pathogens in protected springs, a public tap, drainage channels, and surface water in Kampala, Uganda from November 2014 to May 2015. Because waterborne disease incidence in Uganda has been shown to increase during the wet seasons, we …
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Understanding the development of gut microbiota and effect of Salmonella Typhimurium infection on gut microbiota in layers
… modulation of immunity, and protection against enteric pathogens. Thus, understanding its role in food-producing animals like chickens is essential because it can act as a source of zoonotic diseases. In chickens, the majority of the research in gut microbiota is focused on broilers and there …
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Genotyping antibiotic resistance properties of escherichia coli and campylobacter jejuni associated with diarrhoea in young children in the Vhembe District
… Africa. While antibiotic resistance among enteric pathogens such as Escherichia coli (E. coli) and Campylobacter spp. is increasing, surveillance of antimicrobial resistance genes (ARG) is limited in Africa. The need for such studies in Africa was demonstrated by our published review of the …
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Further characterisation of the envelope stress responses of Salmonella Typhimurium
Salmonella serovars are enteric pathogens of economic and clinical importance. The ability of Salmonella spp. to sense and adapt to exogenous stresses contributes towards infection severity and prevalence. The envelope stress responses promote survival within and between hosts by maintaining …
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Endogenous production and detoxification of a potent cytotoxin, nitric oxide, in Salmonella enterica serovar Typhimurium and Escherichia coli
Salmonella serovars are harmful enteric pathogens of economical and clinical importance that possess sophisticated strategies to rapidly adapt to various host (human and animal) and non-host (soil, water and industrial) environments. Nitrosative stress, in the form of RNS such as the potent …
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Molecular characterization of economically important poultry viruses in western Canada
… Hemorrhagic Enteritis Virus (HEV) are important enteric pathogens affecting poultry production around the world. These agents are the causative agents of Viral Arthritis (VA), White Chick Syndrome (WCS), and Hemorrhagic Enteritis (HE), respectively. In meat-type chickens, pathogenic strains of …
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The epidemiology & molecular basis of fluoroquinolone resistant & susceptible isolates of Campylobacter coli
… from pigs on two separate pig farms. C. coli are enteric pathogens of humans and animals and although diarrhoea resulting from C. coli and C. jejuni is generally a self-limiting disease, in severe cases, fluoroquinolones are the choice antibiotic for treatment. The presence of fluoroquinolone …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating human enterovirus 71 (EV71) infection and immunity, and vaccine and therapeutics for human rotavirus (HRV). Gn pigs could …
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Novel Time-Integrated Quantification of Sediment-Associated Fecal Indicator Bacteria in Rural Alabama Creek with Straight Pipes
… grab samples alone are inadequate to monitor enteric pathogens in a body of water due to the highly variable nature of surface water microbes. We present the novel use of the bi-directional time-integrated mass sediment samplers (TIMS) as an accurate and efficient technology for capturing and …
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Self-assembly of human defensin 6 and its role in innate immunity and siderophore-based strategies to target Gram-Negative bacteria
… (GIcEnt), which are virulence factors of certain enteric pathogens, such as Salmonella spp. The first approach relies on the use of GlcEnt-[beta]-lactam conjugates to target these pathogens. In addition to enhanced uptake efficiency of the drug into bacteria, GIcEnt specifically delivers the …
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