Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Ensheathment"”.
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
… in-vitro models to investigate oligodendrocyte ensheathment behaviour. Current models often employ engineered nano- or micro-fibres to simulate neuronal axons but frequently lack electrical conductivity. To address this gap, this thesis introduces novel conductive fibres made from …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
… We demonstrate that the extent of myelin ensheathment by rat oligodendrocytes is sensitive to the Young’ modulus, diameter, and density of axons, indicating that each of these biophysical cues may play a causal role in influencing an oligodendrocyte’s propensity to myelinate. We further …
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Investigation of the role of polyploidization in glial cells during the development of the drosophila nervous system
… when WG ploidy was reduced, we found that axonal ensheathment is defective. We also established that the three WG per peripheral nerve differentially contribute to overall ploidy. Axonal ensheathment throughout the entire nerve seems to be dependent on position along the anterior-posterior larval …
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State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signaling in neurosecretory neurons
… remodeling, including reduced neuronal ensheathment by astrocyte processes, resulted in blunted GLT1 efficacy, enhanced tonic INMDA strength, and increased neuronal activity. Taken together, our studies support the view that glial modulation of tonic INMDA activation contributes to …
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Investigating the role of microglia in myelin development
… in early development that consists of the ensheathment of axons by myelin, which ensures rapid conduction of action potentials. Although myelination is predominantly driven by oligodendrocytes, the other glial cells, including microglia also contribute to this process. Microglia are …
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Migration of olfactory ensheathing cells grafted into adult rat spinal cord
… are non-myelinating glial cells that provide ensheathment for axons of the olfactory nerve in vivo. OECs have been shown to facilitate the regeneration of CNS axons, to assemble a myelin sheath around demyelinated axons, and it has been suggested OECs migrate very well within the …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… I show that complement is required for phagocyte ensheathment of excitatory cells and the subsequent removal of perisomatic inhibitory synapses on these cells (albeit not through the classical pathway). Together, these studies highlight a novel role for complement in mediating synapse-type and …