Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Enhancer of split"”.
-
A novel genome-wide approach to identify in vivo targets of Notch signalling
… and apoptosis. Despite the importance of this pathway, few targets have been identified, with the Hes (Hairy and Enhancer-of-split) protein family being the best-characterised group of downstream effectors. I have established transgenic mice carrying Biotin Acceptor Peptide (BAP)- …
-
Studies of the hindbrain roof plate organiser in the chick embryo
Organisers are specialised groups of cells that non-autonomously pattern adjacent cell populations. The dorsal midline, or roof plate, of the developing CNS is one such organiser and is required for the specification of specific subtypes of dorsal neurons. Organisers often comprise boundaries …
-
Transcriptional and Post-Translational Mechanisms Contribute to Maintenance of Rest In Neural Tumors
… factor (REST) is an important regulator of normal nervous system development. It negatively regulates neuronal lineage specification in neural progenitors by binding to its consensus <em>RE-1</em> element(s) located in the regulatory region of its target neuronal differentiation genes. …
-
The subnuclear localisation of Notch responsive genes
Title: The subnuclear localisation of Notch responsive genes. Candidate Name: Matthew Jones Notch signalling is a highly conserved cell-cell communication pathway with critical roles in metazoan development and mutations in Notch pathway components are implicated in many types of cancer. Notch is …
-
The Notch Target Hes4 Promotes Osteosarcoma Tumor Growth and Metastasis By Inhibiting Osteogenic Differentiation, and Has Potential As A Prognostic Biomarker For Newly Diagnosed Patients With High Grade Osteosarcoma.
… biomarkers for osteosarcoma (OS) at the time of diagnosis. Although response to preoperative chemotherapy correlates with metastasis risk and overall survival, this information is obtained 3-4 months after the initial diagnosis. The major purpose of this study is to identify clinically …
-
The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
… factor Midline (Mid) exhibits a high degree of structural and functional conservation with its vertebrate homolog Tbx-20. Both Mid and Tbx-20 regulate cell-fate specification with in diverse tissues including the central nervous system (CNS) and heart. Although, some important studies …
-
Understanding the role of the Notch intracellular domain in transcription hub formation
… pathway whose activity controls the expression of many targets in a context dependent manner. Despite the complexity of response, the core pathway is simple. Upon ligand binding, the Notch receptor is cleaved and the Notch intracellular domain (NICD) translocates to the nucleus. In Drosophila …
-
Etablierung und Charakterisierung einer Tetracyclin-induzierbaren PHD2-Knockdown-HeLa-Zelllinie
… 1-3 (PHD1-3) sind sauerstoffabhängige Enzyme, die den Hypoxie-induzierbaren Faktor (HIF-1α) hydroxylieren und damit für den Abbau markieren. HIF-1 ist ein Transkriptionsfaktor, der die Expression von mehr als 70 Genen reguliert, die im weitesten Sinne für die Sauerstoff- …
-
AN INVESTIGATION OF THE MECHANISMS OF GROUCHO MEDIATED TRANSCRIPTIONAL REPRESSION
Groucho (Gro) is the Drosophila member of an evolutionarily conserved family of proteins that act as co-repressors for a wide range of transcription factors and includes four orthologs in humans, known as Transducin-like enhancer of split proteins (TLE1-4). This family of co-repressors play crucial …
-
The Regulation of Segmentation Clock Period in Zebrafish
Oscillations are present at many different levels of biological organization. The cell cycle that directs the division of individual cells, the regular depolarization of neurons in the sinu-atrial node which underlies the regular beating of the heart, the circadian rhythms that govern the daily …
-
Regulation der Neurogenese durch bHLH-O-Proteine in Xenopus laevis
bHLH-Aktivatoren und bHLH-Repressoren sind an zahlreichen Entwicklungsprozessen, einschließlich der Ausbildung des Nervensystems, in Vertebraten und Invertebraten beteiligt. Bei der Bestimmung neuraler Zellschicksale und der Regulation der Neurogenese spielen insbesondere bHLH-O-Proteine eine …