Global ETD Search
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Showing 1 to 19 of 19 for “"Enhancer of Zeste"”.
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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
… Previous studies showed constitutive activation of KRAS (KRASG12D) is a key genetic driver of PDAC, accelerated by deletion of the epigenetic regulator Enhancer of Zeste Homologue 2 (EZH2). However, contradictory findings suggest multiple roles for EZH2. The goal of this study was to define …
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Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
… responsible for regulating appropriate turnover of proteins involved in numerous signaling pathways and biological processes including immune response, DNA damage response, DNA replication, epigenetics and cell division. USP7s role in epigenetics is emerging and studies have demonstrated that …
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The molecular mechanisms of pseudogene-mediated PTEN expression.
… gene and mutations to the PTEN gene are often a precursor to the development of cancerous cells, common in many different types of cancer including prostate, breast and brain cancers. PTEN regulation is fine-tuned by the PTEN pseudogene, PTENpg1, and its two antisense RNAs. A number of …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
<p>During the process of tumorigenesis, inactivation of tumor suppressors is a critical step. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and the enzymatic core subunit of polycomb repressive complex 2 (PRC2), promotes cell growth and migration through catalyzing trimethylation …
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Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
<p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyzes the trimethylation of histone H3 on lysine 27 (H3K27Me3), to repress gene transcription. Many types of cancer stem and progenitor cells, including breast, have demonstrated EZH2 to …
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EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
The disruption of chromatin modifiers during cortical neurogenesis is one of the underlying causes of neurodevelopmental and intellectual disability disorders. We recently found EZH1 loss and gain of function (LOF and GOF) variants as the genetic basis of overlapping novel neurodevelopmental …
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Zika Modulates Arthropod Histone Methylation in Mosquito Cells
<p>Epigenetics is the heritable series of covalent modifications that affect chromatin structure, gene expression, and protein function. Methylation is one such epigenetic modification that involves the addition of chemical modifying entities, such as methyl groups, on nucleic acids or proteins. …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… complex 2 (PRC2) catalyses the methylation of ‘Lys-27’ of histone H3, leading to transcriptional repression of target genes through its catalytic subunit Enhancer of zeste homolog 1/2 (EZH1/2). PRC2 functions as a critical regulator of stem cells in mouse embryonic and adult tissues. …
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Determinants of piRNA precursor transcription and export in Drosophila melanogaster
… genomic integrity against the harmful effects of transposon mobilisation in animal gonads. The majority of piRNAs originates from discrete source loci named piRNA clusters. In Drosophila germ cells, most piRNAs are produced from both genomic strands of so-called ‘dual-strand’ cluster loci. …
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Xenoestrogen-Specific Mechanisms of Developmental Reprogramming Correlate With Gene Expression and Tumor Development
Environmental exposures during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life in a process known as developmental reprogramming. We have shown that neonatal exposure to the xenoestrogen diethylstilbestrol (DES) can …
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Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… Leukemia (CLL) is the most common form of leukemia diagnosed in Western countries and is characterized by clonal expansion of B cells. The clinical course of CLL is diverse and nearly 50% of patients present with chromosomal abnormalities. Deletion of the short arm on chromosome 17 …
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Novel pathways of human host defence against Mycobacterium tuberculosis
… tuberculosis (Mtb), the primary cause of tuberculosis (TB). An improved understanding of host factors that affect Mtb clearance by macrophages, the most important cell for Mtb defence, has the potential to improve treatment regimens for TB. My thesis describes how virulent double …
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COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
Pharmacologic reversal of epigenetic events including histone modification and DNA methylation has a therapeutic potential in cancer treatment through inducing cancer cell apoptosis. 3-deazaneplanocin A (DZNep) appears to be a unique chromatin remodelling (epigenetic) compound that can deplete the …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL require treatment for clinically significant symptoms of menorrhagia, severe pain, …
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A role for myotubularins in vaccinia virus egress
… virus (VACV) generates multiple distinct forms of infectious virus. Intracellular mature virus (IMV) particles are surrounded by a single lipid membrane and are mostly released upon lysis of the infected cell. Some IMVs are wrapped by an additional double membrane to form intracellular enveloped …
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Characterization of Tcl1-Tg:P53-/- Mice That Resemble Human Chronic Lymphocytic Leukemia With 17P-Deletion
… Statesand Europe. CLL patients with deletion of chromosome 17p, where the tumor suppressor p53 gene is located, often develop a more aggressive disease with poor clinical outcomes. However, the underlying mechanism remains unclear. In order to understand the underneath mechanism <em>in …
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Fasting alters histone methylation in paraventricular nucleus of chick through regulating of polycomb repressive complex 2
… influences. Unfavorable nutrition is one kind of stress that can cause acute metabolic disorders during the neonatal period [1,2,3] and severe diseases in later life [4,5]. These early life experiences occurring during heightened periods of brain plasticity help determine the lifelong …
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Tnf Signaling During Tissue Damage-Induced Nociceptive Sensitization In Drosophila
… vertebrates. In <em>Drosophila</em> larval model of nociceptive sensitization, UV irradiation in results in epidermal apoptosis and thermal allodynia. TNF/Eiger is produced from dying epidermal cells and acts its receptor in nociceptive sensory neurons to induce thermal allodynia. Inhibition of …