Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Engram"”.
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Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory
How a transient experience creates an enduring yet dynamic memory remains a fundamental unresolved issue in studies of memory. Experience-dependent aggregation of the RNA-binding protein CPEB/Orb2 is one of the candidate mechanisms of memory maintenance. Here, using tools that allow rapid and …
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Neurobiological mechanisms underlying episodic memory retrieval
… the representation of a specific memory, memory engram cells, in the brain. First, using animal models of retrograde amnesia, we demonstrated that direct activation of amnesic engram cells in the hippocampus resulted in robust memory retrieval, indicating the persistence of the original memory. …
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Engrams, Neurogenesis, and Forgetting
… forgetting can be overcome via a dentate gyrus engram ‘tag-and-activate’ strategy. Optogenetic stimulation of dentate gyrus encoding neural ensembles recovered ‘lost’ infant memories even 90 days following the initial learning event. In a process akin to pattern completion, memory recovery was …
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Tracking Light-Induced Synaptic Engrams in in-vitro Neuronal Networks
… within memory circuits, often referred to as engrams. Advancing our understanding of synaptic strength and plasticity in living organisms, especially within natural behavioral contexts, faces significant challenges due to limitations in available measurement and control tools. To address this …
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Localizing engrams of olfactory memories in Drosophila
Zars and co-workers were able to localize an engram of aversive olfactory memory to the mushroom bodies of Drosophila (Zars et al., 2000). In this thesis, I followed up on this finding in two ways. Inspired by Zars et al. (2000), I first focused on the whether it would also be possible to localize …
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis
… project, we investigated cFos+ cells in a memory engram study, showcasing MorPheT’s utility for brain-wide analysis of engram cells. By examining regions hypothesized to hold memory engrams for contextual fear conditioning memory, we identified brain regions where engrams for a specific memory are …
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Hippocampal microcircuits for social memory specification
… and identified social recognition memory engram in downstream ventral CA1 (vCA1). However, the anatomical site for the storage of social specification memory and its underlying neuroscientific mechanisms are poorly known. Here, we report that social specification memory engrams are stored …
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Illuminating the mental memoriam
… historical studies that lead to the modem memory engram theory. Then, I present our recent advances in memory research that combine transgenic and optogenetic approaches to reveal underlying neuronal substrates sufficient for activating mnemonic processes. Our studies' conclusions are threefold: …
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Analysis of The Distributed Representation of Operant Memory In Aplysia
… Some sites of plasticity participating in the engram underlying an example of operant memory in <em>Aplysia </em>have been previously uncovered. Three studies are described here that sought to draw closer to a thorough characterization of this memory. The first study used a computational model …
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Scalable platforms for computation and memory in living cells
… cell lineage mapping with tunable resolution (ENGRAM - Chapter 5), continuous in vivo evolution and synthetic Lamarckian evolution (DRIVE - Chapter 6), tunable and multifunctional transcriptional factors for gene regulation in eukaryotes (crisprTF - Chapter 7), and an unbiased, high-throughput …
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The Medial Entorhinal Cortex's role in temporal and working memory : characterization of a mouse lacking synaptic transmission in Medial Entorhinal Cortex Layer III
… that acquisition and recall of the same memory engram do not require the exact same anatomy. Additionally, this pathway is necessary for performance in a delayed nonmatch-to-place working memory task, in which the animal must utilize memory from the previous trial to successfully complete the …