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Showing 1 to 11 of 11 for “"Engineering cartilage"”.
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Tissue Engineering Cartilage with a Composite Electrospun and Hydrogel Scaffold
… by degeneration and loss of articular cartilage which leads to pain, and loss of joint motility and function. Individuals suffering from severe osteoarthritis are commonly treated with full knee replacements. The procedure does eliminate the problem of degrading cartilage tissue; …
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Application of Cell-Derived Extracellular Matrix (ECM) Scaffold on Tissue Engineering Cartilage
"In recent years, cartilage tissue engineering for reconstruction or repair of a cartilage injury has been emerged as alterative solutions based on the application of selected chondrocytes and scaffold. The purpose of present study is to evaluate the feasibility of novel cell-derived extracellular …
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Engineering Dynamic Granular Composites for the Repair of Cartilage Tissue
… composites were investigated for injectable cartilage tissue repair, dynamic tissue shape morphing, and 4D bioprinting, where features such as microgel micromechanical properties, volume ratios of spheroids and microgels, rate of microgel degradation, and overall spatial positioning of …
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
Articular cartilage provides a bearing surface for transmitting forces across joints. The poor ability of cartilage to self-repair has motivated efforts to engineer replacement tissues, and mesenchymal stem cells (MSCs), which can undergo chondrogenesis, have emerged as a promising cell source. To …
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Management of cartilage deficiency by applying extracellular matrix membrane on bone marrow stimulation technique and evaluating the quality of repaired cartilage
Articular cartilage is a resilient load-bearing tissue that forms the articulating surface of diarthrodial joints and provides low friction, lubrication, and wearless characteristics necessary for repetitive gliding motion. However, because articular cartilage has neither vascular nor lymphatic …
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Decellularized cartilage as a chondroinductive material for cartilage tissue engineering
Cartilage defects, whether caused by osteoarthritis, joint trauma, or other disease, have provoked a wide variety of tissue engineering scaffold strategies in recent years. Traditionally, cartilage tissue engineering scaffolds have utilized synthetic polymer components to form hydrogels or other …
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The Influence of Manufacturing Method and Collagen on the Mechanical Performance of Sodium Alginate-Based Scaffolds for Cartilage Tissue Engineering
Cartilage has limited ability to repair itself making it a good candidate for artificial tissue replacements. Hydrogels such as sodium alginate (SA) have been used in bioprinting and tissue engineering for their favourable properties, however, the mechanical performance of engineered tissue …
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Controlling Tissue Matrix Assembly of Human Mesenchymal Stem Cells toward Engineering Native-like Bone, Cartilage, and Osteochondral Grafts
Medical complications caused by bone, cartilage, and osteochoondral defects present special challenges to tissue engineers. An ability to fabricate these tissues in vitro will eliminate clinical complications caused by current techniques used in graft reconstruction. These complications include …
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Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering
Cartilage has a limited endogenous ability for self-repair and current clinical treatments for damaged or diseased cartilage tissue are insufficient. Additionally, there is a biological and mechanical interplay between cartilage and the underlying subchondral bone, linking the …
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Development of Cartilage-Derived Matrix Scaffolds via Crosslinking, Decellularization, and Ice-Templating
<p>Articular cartilage is a connective tissue that lines the surfaces of diarthrodial joints; and functions to support and distribute loads as wells as facilitate smooth joint articulation. Unfortunately, cartilage possesses a limited capacity to self-repair. Once damaged, cartilage continues to …
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Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
The predominant approach for cartilage tissue engineering involves cell transplantation with or without cytokine delivery, biomaterial scaffolds, bioreactors, applied mechanical stimulation and altered oxygen tension. Despite its scientific merit, cell delivery faces drawbacks including scarce cell …